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    Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 [ Mus musculus (house mouse) ]

    Gene ID: 337924, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp3a44provided by MGI
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 44provided by MGI
    Primary source
    MGI:MGI:2449818
    See related
    Ensembl:ENSMUSG00000054417 AllianceGenome:MGI:2449818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable demethylase activity; retinoic acid 4-hydroxylase activity; and steroid hydroxylase activity. Predicted to be involved in several processes, including estrogen metabolic process; lipid hydroxylation; and retinoic acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver adult (RPKM 30.2) See more
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    Genomic context

    See Cyp3a44 in Genome Data Viewer
    Location:
    5 G2; 5 85.17 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145710793..145742701, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145773983..145805891, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 41A Neighboring gene selenoprotein K, pseudogene 2 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 44 pseudogene Neighboring gene predicted gene, 38744

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables demethylase activity  
    enables estrogen 16-alpha-hydroxylase activity  
    enables oxidoreductase activity  
    enables retinoic acid 4-hydroxylase activity  
    enables testosterone 6-beta-hydroxylase activity  
    enables testosterone 6-beta-hydroxylase activity  
    Process Evidence Code Pubs
    involved_in alkaloid catabolic process  
    involved_in estrogen metabolic process  
    involved_in lipid hydroxylation  
    involved_in oxidative demethylation  
    involved_in oxidative demethylation  
    involved_in retinoic acid metabolic process  
    involved_in steroid metabolic process  
    involved_in steroid metabolic process  
    involved_in xenobiotic catabolic process  
    involved_in xenobiotic metabolic process  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    cytochrome P450, family 3, subfamily a, polypeptide 44
    Names
    cytochrome P450, 3a44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177380.3NP_796354.1  cytochrome P450, family 3, subfamily a, polypeptide 44

      See identical proteins and their annotated locations for NP_796354.1

      Status: PROVISIONAL

      Source sequence(s)
      AC166648
      Consensus CDS
      CCDS19864.1
      UniProtKB/TrEMBL
      Q9EQW4
      Related
      ENSMUSP00000069932.6, ENSMUST00000067479.6
      Conserved Domains (1) summary
      pfam00067
      Location:39494
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145710793..145742701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_868675.1 RNA Sequence

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