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    Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) [ Mus musculus (house mouse) ]

    Gene ID: 14800, updated on 17-Dec-2024

    Summary

    Official Symbol
    Gria2provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, AMPA2 (alpha 2)provided by MGI
    Primary source
    MGI:MGI:95809
    See related
    Ensembl:ENSMUSG00000033981 AllianceGenome:MGI:95809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GluA2; Glur2; GluR-B; Glur-2; gluR-K2
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in CNS E18 (RPKM 50.8), frontal lobe adult (RPKM 41.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Gria2 in Genome Data Viewer
    Location:
    3 E3; 3 35.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (80588757..80711534, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (80681450..80804227, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330069K06 gene Neighboring gene STARR-seq mESC enhancer starr_08017 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene STARR-seq mESC enhancer starr_08018 Neighboring gene predicted gene, 57716 Neighboring gene glycine receptor, beta subunit Neighboring gene polymerase (DNA directed), iota pseudogene Neighboring gene predicted gene, 54207

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity  
    enables AMPA glutamate receptor activity  
    enables AMPA glutamate receptor activity  
    enables PDZ domain binding  
    enables SNARE binding  
    enables amyloid-beta binding  
    enables cytoskeletal protein binding  
    enables extracellularly glutamate-gated ion channel activity PubMed 
    enables glutamate receptor binding  
    enables glutamate-gated receptor activity PubMed 
    enables glutamate-gated receptor activity  
    enables identical protein binding  
    enables immunoglobulin binding  
    enables ionotropic glutamate receptor binding  
    enables kainate selective glutamate receptor activity  
    enables kainate selective glutamate receptor activity  
    enables ligand-gated monoatomic cation channel activity  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein-containing complex binding  
    enables scaffold protein binding  
    enables signaling receptor activity  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in cellular response to brain-derived neurotrophic factor stimulus  
    involved_in cellular response to glycine  
    acts_upstream_of_or_within chemical synaptic transmission PubMed 
    involved_in chemical synaptic transmission  
    involved_in establishment of protein localization  
    involved_in excitatory postsynaptic potential  
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in modulation of chemical synaptic transmission  
    involved_in monoatomic cation transmembrane transport  
    involved_in positive regulation of synaptic transmission  
    involved_in protein tetramerization  
    involved_in receptor internalization  
    involved_in regulation of receptor recycling  
    involved_in regulation of synaptic transmission, glutamatergic  
    involved_in synaptic transmission, glutamatergic  
    Items 1 - 20 of 53
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex  
    part_of AMPA glutamate receptor complex PubMed 
    part_of AMPA glutamate receptor complex  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse  
    located_in asymmetric synapse  
    located_in axon  
    located_in cell surface  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendrite cytoplasm  
    located_in dendrite membrane  
    located_in dendritic shaft  
    is_active_in dendritic spine  
    located_in dendritic spine  
    located_in dendritic spine head  
    located_in dendritic spine neck  
    located_in endoplasmic reticulum PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in growth cone  
    located_in membrane PubMed 
    located_in neuron projection PubMed 
    located_in neuronal cell body  
    located_in perikaryon  
    located_in perisynaptic space PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density PubMed 
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane PubMed 
    located_in postsynaptic density membrane PubMed 
    is_active_in postsynaptic density membrane  
    located_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane  
    located_in presynapse  
    is_active_in presynaptic active zone membrane  
    is_active_in presynaptic membrane  
    located_in presynaptic membrane  
    part_of protein-containing complex  
    located_in somatodendritic compartment PubMed 
    located_in spine synapse  
    located_in synapse PubMed 
    located_in synapse  
    located_in synaptic membrane PubMed 
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  
    located_in terminal bouton  
    Items 1 - 20 of 53

    General protein information

    Preferred Names
    glutamate receptor 2
    Names
    AMPA selective glutamate receptor
    AMPA-selective glutamate receptor 2
    glutamate receptor B
    glutamate receptor ionotropic, AMPA 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039195.3NP_001034284.2  glutamate receptor 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs at the 3' end compared to transcript variant 1, and encodes a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC121908, AC163349
      UniProtKB/TrEMBL
      C9K0Z1
      Related
      ENSMUST00000194383.6
    2. NM_001083806.3NP_001077275.2  glutamate receptor 2 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform).
      Source sequence(s)
      AC121908, AC163349
      Consensus CDS
      CCDS38459.1
      UniProtKB/TrEMBL
      E9QKC0, Q4LG64
      Related
      ENSMUSP00000103374.2, ENSMUST00000107745.8
      Conserved Domains (2) summary
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06389
      Location:28398
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    3. NM_001357924.2NP_001344853.2  glutamate receptor 2 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC121908, AC163349
      UniProtKB/TrEMBL
      Q4LG64
      Conserved Domains (2) summary
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06389
      Location:28398
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    4. NM_001357927.2NP_001344856.2  glutamate receptor 2 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC121908, AC163349
      UniProtKB/Swiss-Prot
      P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3
      Conserved Domains (2) summary
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06389
      Location:28398
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    5. NM_013540.4NP_038568.3  glutamate receptor 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences.
      Source sequence(s)
      AC121908, AC163349
      Consensus CDS
      CCDS17423.1
      UniProtKB/Swiss-Prot
      P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3
      UniProtKB/TrEMBL
      G5E8H1
      Related
      ENSMUSP00000074787.5, ENSMUST00000075316.10
      Conserved Domains (2) summary
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06389
      Location:28398
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

    RNA

    1. NR_152147.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC121908, AC163349
    2. NR_152148.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC121908, AC163349
    3. NR_152149.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC121908, AC163349, AI841956

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      80588757..80711534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501014.4XP_006501077.1  glutamate receptor 2 isoform X1

      UniProtKB/TrEMBL
      C9K0Z1
      Related
      ENSMUSP00000141447.2, ENSMUST00000192463.2
      Conserved Domains (2) summary
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06389
      Location:28398
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

    RNA

    1. XR_004941283.1 RNA Sequence

    2. XR_003954287.1 RNA Sequence

    3. XR_004941289.1 RNA Sequence

    4. XR_375488.4 RNA Sequence

    5. XR_001783655.3 RNA Sequence

    6. XR_001783653.3 RNA Sequence

    7. XR_003954286.1 RNA Sequence

    8. XR_003954284.2 RNA Sequence

    9. XR_003954283.2 RNA Sequence

    10. XR_001783662.3 RNA Sequence

    11. XR_003954288.2 RNA Sequence

    12. XR_004941284.1 RNA Sequence

    13. XR_001783652.3 RNA Sequence

    14. XR_001783657.3 RNA Sequence

    15. XR_001783656.3 RNA Sequence

    16. XR_003954285.2 RNA Sequence

    17. XR_001783654.3 RNA Sequence

    18. XR_004941287.1 RNA Sequence

    19. XR_004941288.1 RNA Sequence

    20. XR_004941286.1 RNA Sequence

    21. XR_003954282.2 RNA Sequence

    22. XR_004941280.1 RNA Sequence

    23. XR_004941279.1 RNA Sequence

    24. XR_004941285.1 RNA Sequence

    25. XR_004941282.1 RNA Sequence

    26. XR_004941281.1 RNA Sequence

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