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    Eif3f eukaryotic translation initiation factor 3, subunit F [ Mus musculus (house mouse) ]

    Gene ID: 66085, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif3fprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Fprovided by MGI
    Primary source
    MGI:MGI:1913335
    See related
    Ensembl:ENSMUSG00000031029 AllianceGenome:MGI:1913335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif3s5; 0610037M02Rik
    Summary
    Enables cysteine-type deubiquitinase activity and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 509.7), stomach adult (RPKM 285.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif3f in Genome Data Viewer
    Location:
    7 E3; 7 57.21 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108533622..108541149)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (108934415..108941942)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 3N Neighboring gene NLR family, pyrin domain containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E703 Neighboring gene predicted gene, 39067 Neighboring gene predicted gene, 32309

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC90606

    Gene Ontology Provided by MGI

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit F
    Names
    deubiquitinating enzyme eIF3f
    eIF-3-epsilon
    eIF3 p47
    eukaryotic translation initiation factor 3, subunit 5 (epsilon)
    NP_079620.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025344.2NP_079620.2  eukaryotic translation initiation factor 3 subunit F

      See identical proteins and their annotated locations for NP_079620.2

      Status: VALIDATED

      Source sequence(s)
      AK136797, AK152037, BC083190
      Consensus CDS
      CCDS21731.1
      UniProtKB/Swiss-Prot
      Q5XJV3, Q9DCH4
      UniProtKB/TrEMBL
      Q3U8X1, Q3UVY8, Q6IRT4
      Related
      ENSMUSP00000033342.7, ENSMUST00000033342.7
      Conserved Domains (1) summary
      cd08064
      Location:96358
      MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      108533622..108541149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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