Gprc5d G protein-coupled receptor, family C, group 5, member D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gprc5dprovided by MGI
Official Full Name: G protein-coupled receptor, family C, group 5, member Dprovided by MGI
Primary source: MGI:MGI:1935037
See related: Ensembl:ENSMUSG00000030205 AllianceGenome:MGI:1935037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein kinase activator activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and respiratory system. Orthologous to human GPRC5D (G protein-coupled receptor class C group 5 member D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.89 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (135082989..135095281, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (135105991..135118283, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPRC5D is involed in the regulation of keratin synthesis in hard epithelial tissue.
Title: The RAIG family member, GPRC5D, is associated with hard-keratinized structures.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)
Targeted (2)

General gene information

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Markers

Gprc5d (e-PCR), detects polymorphism
- UniSTS:536580

NoName (e-PCR)
- UniSTS:491532

D4Got142 (e-PCR)
- UniSTS:113807

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in hair cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in keratinization	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor family C group 5 member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205396.1 → NP_001192325.1 G-protein coupled receptor family C group 5 member D isoform 1

See identical proteins and their annotated locations for NP_001192325.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC131718, AF218809, AK137739

Consensus CDS

CCDS57462.1

UniProtKB/Swiss-Prot

Q8CJI0, Q8CJI1, Q9JIL6

UniProtKB/TrEMBL

Q3UUY8

Related

ENSMUSP00000032327.8, ENSMUST00000032327.14

Conserved Domains (1) summary

cd15279
Location:21 → 267

7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D
NM_053118.1 → NP_444348.1 G-protein coupled receptor family C group 5 member D isoform 2

See identical proteins and their annotated locations for NP_444348.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AF218809

Consensus CDS

CCDS39680.1

UniProtKB/TrEMBL

Q0VEL2

Related

ENSMUSP00000107553.2, ENSMUST00000111922.2

Conserved Domains (1) summary

pfam00003
Location:61 → 264

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR