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    Nrsn1 neurensin 1 [ Mus musculus (house mouse) ]

    Gene ID: 22360, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrsn1provided by MGI
    Official Full Name
    neurensin 1provided by MGI
    Primary source
    MGI:MGI:894662
    See related
    Ensembl:ENSMUSG00000048978 AllianceGenome:MGI:894662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vmp; Neuro-p24; Neurensin-1
    Summary
    Involved in nervous system development. Located in cytoplasmic vesicle; growth cone; and neuronal cell body. Is expressed in several structures, including adrenal gland; eye; gonad; gut; and nervous system. Orthologous to human NRSN1 (neurensin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 110.6), frontal lobe adult (RPKM 100.2) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Nrsn1 in Genome Data Viewer
    Location:
    13 A3.1; 13 11.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25436022..25453979, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (25252039..25269996, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene MRS2 magnesium transporter Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene doublecortin domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene STARR-seq mESC enhancer starr_33994 Neighboring gene predicted gene, 34122 Neighboring gene triosephosphate isomerase related sequence 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in nervous system development  
    involved_in nervous system development PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle PubMed 
    located_in growth cone PubMed 
    located_in membrane  
    is_active_in neuron projection  
    located_in neuron projection PubMed 
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    is_active_in transport vesicle  
    located_in transport vesicle  

    General protein information

    Preferred Names
    neurensin-1
    Names
    vesicular membrane protein of 24 kDa
    vesicular membrane protein p24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426601.1NP_001413530.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799
    2. NM_001426602.1NP_001413531.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799
    3. NM_001426603.1NP_001413532.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799
      Related
      ENSMUSP00000128979.2, ENSMUST00000167305.2
    4. NM_001426604.1NP_001413533.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799
    5. NM_001426605.1NP_001413534.1  neurensin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589766
    6. NM_009513.2NP_033539.1  neurensin-1 isoform 1

      See identical proteins and their annotated locations for NP_033539.1

      Status: VALIDATED

      Source sequence(s)
      AU080650, BC052019
      Consensus CDS
      CCDS26387.1
      UniProtKB/Swiss-Prot
      P97799
      Related
      ENSMUSP00000055048.7, ENSMUST00000057866.13
      Conserved Domains (1) summary
      pfam14927
      Location:24154
      Neurensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      25436022..25453979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315503.2XP_017170992.1  neurensin-1 isoform X1

      UniProtKB/Swiss-Prot
      P97799
      Conserved Domains (1) summary
      pfam14927
      Location:24154
      Neurensin
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