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    Galactose oxidase/kelch repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819019, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Galactose oxidase/kelch repeat superfamily protein
    Primary source
    TAIR:AT2G44130
    Locus tag
    AT2G44130
    See related
    Araport:AT2G44130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6E13.26; KISS ME DEADLY 3; KMD3
    Summary
    Encodes a member of a family of F-box proteins, called the KISS ME DEADLY (KMD) family.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (18253610..18255054)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Seven transmembrane MLO family protein Neighboring gene Ribosomal protein L30/L7 family protein Neighboring gene Peptidase family C54 protein Neighboring gene histone-lysine N-methyltransferase ASHH3 Neighboring gene methylenetetrahydrofolate reductase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis F-box/Kelch-repeat protein At2g44130 is upregulated in giant cells and promotes nematode susceptibility. Curtis RH, et al. Mol Plant Microbe Interact, 2013 Jan. PMID 23075039
    2. SCF(KMD) controls cytokinin signaling by regulating the degradation of type-B response regulators. Kim HJ, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23720308, Free PMC Article
    3. Down-regulation of Kelch domain-containing F-box protein in Arabidopsis enhances the production of (poly)phenols and tolerance to ultraviolet radiation. Zhang X, et al. Plant Physiol, 2015 Feb. PMID 25502410, Free PMC Article
    4. A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins. Kuroda H, et al. PLoS One, 2012. PMID 23166809, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis KFB39, a close homolog of AtKFB50, also interacts physically with PAL isozymes and modulates PAL stability and activity.[KFB39]
      Title: Down-regulation of Kelch domain-containing F-box protein in Arabidopsis enhances the production of (poly)phenols and tolerance to ultraviolet radiation.
    2. Data indicate that a family of F-box proteins, called the kiss me deadly (KMD) family KMD1-4, targets type-B ARR proteins (ARR1) for degradation.
      Title: SCF(KMD) controls cytokinin signaling by regulating the degradation of type-B response regulators.
    3. the F-box/Kelch-repeat protein At2g44130 is specifically induced by the root-knot nematode Meloidogyne incognita during the initial stages of the initiation and maintenance of the feeding site.
      Title: The Arabidopsis F-box/Kelch-repeat protein At2g44130 is upregulated in giant cells and promotes nematode susceptibility.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129976.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cytokinin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of phenylpropanoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Galactose oxidase/kelch repeat superfamily protein
    NP_566009.1
    • Galactose oxidase/kelch repeat superfamily protein; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 1 (InterPro:IPR006652), Kelch related (InterPro:IPR013089), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: Galactose oxidase/kelch repeat superfamily protein (TAIR:AT3G59940.1); Has 5544 Blast hits to 3569 proteins in 209 species: Archae - 8; Bacteria - 363; Metazoa - 3928; Fungi - 26; Plants - 960; Viruses - 5; Other Eukaryotes - 254 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18253610..18255054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129976.2 → NP_566009.1  Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566009.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80582, Q8L9E8
      UniProtKB/TrEMBL
      A0A178VUS0, A0A7G2EH98
      Conserved Domains (4) summary
      smart00612
      Location:201 → 238
      Kelch; Kelch domain
      smart00256
      Location:23 → 63
      FBOX; A Receptor for Ubiquitination Targets
      PHA03098
      Location:142 → 283
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:143 → 185
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80582.2

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