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    LAC5 laccase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818630, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LAC5
    Official Full Name
    laccase 5
    Primary source
    TAIR:AT2G40370
    Locus tag
    AT2G40370
    See related
    Araport:AT2G40370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    laccase 5; T3G21.14; T3G21_14
    Summary
    putative laccase, a member of laccase family of genes (17 members in Arabidopsis).
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    Genomic context

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    See LAC5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (16857959..16860779, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene prenylated RAB acceptor 1.B2 Neighboring gene neuronal PAS domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-order mutants reveal an essential requirement for peroxidases but not laccases in Casparian strip lignification. Rojas-Murcia N, et al. Proc Natl Acad Sci U S A, 2020 Nov 17. PMID 33139576, Free PMC Article
    2. MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis. Abdel-Ghany SE, et al. J Biol Chem, 2008 Jun 6. PMID 18408011, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    NM_129597.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroquinone:oxygen oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Casparian strip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    laccase 5
    NP_181568.1
    • laccase 5 (LAC5); FUNCTIONS IN: laccase activity; INVOLVED IN: response to copper ion; LOCATED IN: endomembrane system, apoplast; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Multicopper oxidase, type 3 (InterPro:IPR011707), Laccase (InterPro:IPR017761), Multicopper oxidase, type 2 (InterPro:IPR011706), Cupredoxin (InterPro:IPR008972), Multicopper oxidase, copper-binding site (InterPro:IPR002355), Multicopper oxidase, type 1 (InterPro:IPR001117); BEST Arabidopsis thaliana protein match is: laccase 12 (TAIR:AT5G05390.1); Has 10120 Blast hits to 8186 proteins in 1337 species: Archae - 37; Bacteria - 4008; Metazoa - 431; Fungi - 3685; Plants - 1575; Viruses - 0; Other Eukaryotes - 384 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16857959..16860779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129597.4 → NP_181568.1  laccase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181568.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIY8
      UniProtKB/TrEMBL
      A0A178VWJ4, A0A5S9X5R1
      Conserved Domains (4) summary
      cd13849
      Location:31 → 147
      CuRO_1_LCC_plant; The first cupredoxin domain of plant laccases
      cd13875
      Location:162 → 309
      CuRO_2_LCC_plant; The second cupredoxin domain of the plant laccases
      cd13897
      Location:424 → 563
      CuRO_3_LCC_plant; The third cupredoxin domain of the plant laccases
      TIGR03389
      Location:27 → 580
      laccase; laccase, plant
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIY8.1

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