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    APC2 anaphase-promoting complex/cyclosome 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815008, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APC2
    Official Full Name
    anaphase-promoting complex/cyclosome 2
    Primary source
    TAIR:AT2G04660
    Locus tag
    AT2G04660
    See related
    Araport:AT2G04660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    anaphase-promoting complex/cyclosome 2; F28I8.30; F28I8_30
    Summary
    a highly conserved ubiquitin-protein ligase involved in cell cycle regulation
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    Genomic context

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    See APC2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (1624630..1629259)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene RNA polymerase Rpb6 Neighboring gene ADP-glucose pyrophosphorylase family protein Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants. Lima Mde F, et al. BMC Plant Biol, 2010 Nov 18. PMID 21087491, Free PMC Article
    2. Specialization of CDC27 function in the Arabidopsis thaliana anaphase-promoting complex (APC/C). Pérez-Pérez JM, et al. Plant J, 2008 Jan. PMID 17944809
    3. The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. Capron A, et al. Plant Cell, 2003 Oct. PMID 14508008, Free PMC Article
    4. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126495.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in megagametogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex/cyclosome 2
    NP_178543.2
    • anaphase-promoting complex/cyclosome 2 (APC2); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin protein ligase binding; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: ubiquitin ligase complex; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cullin homology (InterPro:IPR016158), Anaphase promoting complex subunit 2 (InterPro:IPR014786), Cullin, N-terminal (InterPro:IPR001373); BEST Arabidopsis thaliana protein match is: cullin4 (TAIR:AT5G46210.1); Has 1400 Blast hits to 1393 proteins in 217 species: Archae - 0; Bacteria - 0; Metazoa - 534; Fungi - 454; Plants - 255; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1624630..1629259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126495.3 → NP_178543.2  anaphase-promoting complex/cyclosome 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178543.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GX39, Q8H1U5, Q9SJ93
      UniProtKB/TrEMBL
      A0A178VYA9, A0A5S9WX64, A0A7G2E7I0
      Conserved Domains (2) summary
      pfam00888
      Location:557 → 735
      Cullin; Cullin family
      pfam08672
      Location:804 → 863
      ANAPC2; Anaphase promoting complex (APC) subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1U5.1

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