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    PIP5K1 phosphatidylinositol-4-phosphate 5-kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838801, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIP5K1
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase 1
    Primary source
    TAIR:AT1G21980
    Locus tag
    AT1G21980
    See related
    Araport:AT1G21980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPIP5K1; ATPIPK1; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; phosphatidylinositol-4-phosphate 5-kinase 1
    Summary
    Type I phosphatidylinositol-4-phosphate 5-kinase. Preferentially phosphorylates PtdIns4P. Induced by water stress and abscisic acid in Arabidopsis thaliana. Expressed in procambial cells of leaves, flowers and roots. A N-terminal Membrane Occupation and Recognition Nexus (MORN)affects enzyme activity and distribution.
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    Genomic context

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    See PIP5K1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (7734661..7738772)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Histone superfamily protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box/RNI-like/FBD-like domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dibasic amino acid pair conserved in the activation loop directs plasma membrane localization and is necessary for activity of plant type I/II phosphatidylinositol phosphate kinase. Mikami K, et al. Plant Physiol, 2010 Jul. PMID 20427464, Free PMC Article
    2. AtPIP5K1, an Arabidopsis thaliana phosphatidylinositol phosphate kinase, synthesizes PtdIns(3,4)P(2) and PtdIns(4,5)P(2) in vitro and is inhibited by phosphorylation. Westergren T, et al. Biochem J, 2001 Nov 1. PMID 11672432, Free PMC Article
    3. Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development. Ugalde JM, et al. Plant Sci, 2016 Sep. PMID 27457979
    4. Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases. Perera IY, et al. FEBS Lett, 2005 Jun 20. PMID 15949803
    5. Arabidopsis phosphatidylinositol phosphate kinase 1 binds F-actin and recruits phosphatidylinositol 4-kinase beta1 to the actin cytoskeleton. Davis AJ, et al. J Biol Chem, 2007 May 11. PMID 17379598

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102047.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol-4-phosphate 5-kinase 1
    NP_173617.1
    • phosphatidylinositol-4-phosphate 5-kinase 1 (PIP5K1); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup (InterPro:IPR016034), Phosphatidylinositol-4-phosphate 5-kinase, plant (InterPro:IPR017163), MORN motif (InterPro:IPR003409), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase 2 (TAIR:AT1G77740.1); Has 28574 Blast hits to 7954 proteins in 630 species: Archae - 0; Bacteria - 3995; Metazoa - 4425; Fungi - 453; Plants - 2526; Viruses - 0; Other Eukaryotes - 17175 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7734661..7738772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102047.4 → NP_173617.1  phosphatidylinositol-4-phosphate 5-kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173617.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22503, O82120, Q56YP2, Q9LM65
      UniProtKB/TrEMBL
      A0A178W750, A0A5S9VGU1
      Conserved Domains (1) summary
      PLN03185
      Location:72 → 748
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56YP2.1

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