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    VEP1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828523, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VEP1
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT4G24220
    Locus tag
    AT4G24220
    See related
    Araport:AT4G24220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    5-steroid-5[beta]-reductase; 5[beta]-StR; AWI31; Delta4; T22A6.50; T22A6_50; VEIN PATTERNING 1
    Summary
    encodes a progesterone-5beta-reductase-like protein. It has enone reductase activity against a wide range of substrates, including 3-oxo-Delta-4,5-steroids in vitro. The in vivo substrates and product of this enzyme have not yet been elucidated but it is likely to participate in steroid metabolism. The protein contains a mammalian death domain involved in programmed cell death. The gene is expressed in the vascular system and mutants carrying a dominant mutation in the gene have defective vascular patterning. VEP1 gene expression is induced specifically by wounding.
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    Genomic context

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    See VEP1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (12564945..12566755)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene F-box family protein Neighboring gene acyl-CoA-binding domain 3 Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Schmidt K, et al. Phytochemistry, 2018 Dec. PMID 30172078
    2. The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L. Herl V, et al. Biochimie, 2009 Apr. PMID 19166903
    3. Involvement of the VEP1 gene in vascular strand development in Arabidopsis thaliana. Jun JH, et al. Plant Cell Physiol, 2002 Mar. PMID 11917087
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The gene VEP1 encoding At5beta-StR was strongly transcribed in stems and leaves.
      Title: The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084969.1
    NM_118555.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Delta4-3-oxosteroid 5beta-reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enone reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_001078438.1
    • VEIN PATTERNING 1 (VEP1); FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: xylem and phloem pattern formation, response to wounding; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT5G58750.1); Has 711 Blast hits to 707 proteins in 202 species: Archae - 0; Bacteria - 240; Metazoa - 0; Fungi - 168; Plants - 221; Viruses - 0; Other Eukaryotes - 82 (source: NCBI BLink).
    NP_194153.1
    • VEIN PATTERNING 1 (VEP1); FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: xylem and phloem pattern formation, response to wounding; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT5G58750.1); Has 706 Blast hits to 702 proteins in 199 species: Archae - 0; Bacteria - 237; Metazoa - 0; Fungi - 166; Plants - 221; Viruses - 0; Other Eukaryotes - 82 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12564945..12566755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118555.4 → NP_194153.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRU3, Q39171, Q9STX2
      UniProtKB/TrEMBL
      A0A178V158, A0A5S9XVU2, A0A7G2F3B7
      Conserved Domains (1) summary
      cd08948
      Location:28 → 348
      5beta-POR_like_SDR_a; progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs

    2. NM_001084969.1 → NP_001078438.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F3B7
      Conserved Domains (2) summary
      cd08948
      Location:27 → 347
      5beta-POR_like_SDR_a; progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs
      pfam01370
      Location:28 → 274
      Epimerase; NAD dependent epimerase/dehydratase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STX2.1

    Gene LinkOut

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