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    RSZ22 serine/arginine-rich 22 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829285, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RSZ22
    Official Full Name
    serine/arginine-rich 22
    Primary source
    TAIR:AT4G31580
    Locus tag
    AT4G31580
    See related
    Araport:AT4G31580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    At-RSZ22; AtRSZ22; F28M20.230; F28M20_230; RS-containing zinc finger protein 22; RS-CONTAINING ZINC FINGER PROTEIN 22; RSZP22; serine/arginine-rich 22; SRZ-22; SRZ22
    Summary
    Encodes a Serine/arginine-rich (SR) protein RSZp22. SR proteins are splicing regulators that share a modular structure consisting of one or two N-terminal RNA recognition motif domains and a C-terminal RS-rich domain. RSZp22 is located in the nucleolus. It is a nucleocytoplasmic shuttling protein and an interacting partner to the Arabidopsis U1-70K. Barta et al (2010) have proposed a nomenclature for Serine/Arginine-Rich Protein Splicing Factors (SR proteins): Plant Cell. 2010, 22:2926.
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    Genomic context

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    See RSZ22 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (15306544..15309035)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene high chlorophyll fluorescence 153 Neighboring gene nucleoporin Neighboring gene Cellulose-synthase-like C5 Neighboring gene UDP-N-acetylglucosamine (UAA) transporter family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel family of plant splicing factors with a Zn knuckle motif: examination of RNA binding and splicing activities. Lopato S, et al. Plant Mol Biol, 1999 Mar. PMID 10350090
    2. Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors. Tillemans V, et al. Plant Cell, 2006 Nov. PMID 17114353, Free PMC Article
    3. Overexpression of an Arabidopsis heterogeneous nuclear ribonucleoprotein gene, AtRNP1, affects plant growth and reduces plant tolerance to drought and salt stresses. Wang Z, et al. Biochem Biophys Res Commun, 2016 Apr 1. PMID 26923071
    4. The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins. Golovkin M, et al. Plant Cell, 1998 Oct. PMID 9761791, Free PMC Article
    5. Dynamic nucleocytoplasmic shuttling of an Arabidopsis SR splicing factor: role of the RNA-binding domains. Rausin G, et al. Plant Physiol, 2010 May. PMID 20237019, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggested that the overexpression of AtRNP1 negatively affects plant growth and abiotic stress tolerance.
      Title: Overexpression of an Arabidopsis heterogeneous nuclear ribonucleoprotein gene, AtRNP1, affects plant growth and reduces plant tolerance to drought and salt stresses.
    2. Functional RNA recognition motif RNP1 and zinc-knuckle are dispensable for the exclusive protein nuclear localization and speckle-like distribution.
      Title: Dynamic nucleocytoplasmic shuttling of an Arabidopsis SR splicing factor: role of the RNA-binding domains.
    3. Data demonstrate that members of different SR protein sub-families, includins RSZ-21,-22, and -33, localise into distinct populations of nuclear speckles with no, partial or complete co-localisation.
      Title: Co-localisation studies of Arabidopsis SR splicing factors reveal different types of speckles in plant cell nuclei.
    4. The dynamic distribution of the Arabidopsis thaliana SR proteins RSZp22 and RSp31 in the nucleolus, are demonstrated.
      Title: Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085005.1
    NM_119307.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    serine/arginine-rich 22
    NP_001078474.1
    • serine/arginine-rich 22 (SRZ-22); FUNCTIONS IN: protein binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: nuclear speck, nucleolus, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: RNA recognition motif and CCHC-type zinc finger domains containing protein (TAIR:AT2G24590.1); Has 12597 Blast hits to 10987 proteins in 687 species: Archae - 4; Bacteria - 845; Metazoa - 6508; Fungi - 1364; Plants - 2624; Viruses - 137; Other Eukaryotes - 1115 (source: NCBI BLink).
    NP_194886.1
    • serine/arginine-rich 22 (SRZ-22); FUNCTIONS IN: protein binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: nuclear speck, nucleolus, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: RNA recognition motif and CCHC-type zinc finger domains containing protein (TAIR:AT2G24590.1); Has 12597 Blast hits to 10987 proteins in 687 species: Archae - 4; Bacteria - 845; Metazoa - 6508; Fungi - 1364; Plants - 2624; Viruses - 137; Other Eukaryotes - 1115 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15306544..15309035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119307.4 → NP_194886.1  serine/arginine-rich 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23646, O81126
      UniProtKB/TrEMBL
      A0A178V2N6, A0A5S9XYC9, A0A654FV12
      Conserved Domains (2) summary
      pfam00098
      Location:100 → 114
      zf-CCHC; Zinc knuckle
      cd12373
      Location:3 → 71
      RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

    2. NM_001085005.1 → NP_001078474.1  serine/arginine-rich 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23646, O81126
      UniProtKB/TrEMBL
      A0A178V2N6, A0A5S9XYC9, A0A654FV12
      Conserved Domains (2) summary
      pfam00098
      Location:100 → 114
      zf-CCHC; Zinc knuckle
      cd12373
      Location:3 → 71
      RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81126.1

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