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    DPB Transcription factor DP [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831847, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DPB
    Official Full Name
    Transcription factor DP
    Primary source
    TAIR:AT5G03415
    Locus tag
    AT5G03415
    See related
    Araport:AT5G03415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDPB; DPB TRANSCRIPTION FACTOR
    Summary
    Encodes a homolog of the animal DP protein. DP, in animals, forms a heterodimer with E2F and plays a central role in G1/S transition in the cell division cycle. DPB has been shown to interact with non phosphorylated E2Fc; when E2Fc is phosphorylated, the formation of the E2Fc/DPB heterodimer is lost.
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    Genomic context

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    See DPB in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (842289..845454)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Class II aaRS and biotin synthetases superfamily protein Neighboring gene 5'-AMP-activated protein kinase-like protein Neighboring gene ncRNA Neighboring gene phosphoadenosine phosphosulfate (PAPS) reductase family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis cell cycle F-box protein SKP2A binds to auxin. Jurado S, et al. Plant Cell, 2010 Dec. PMID 21139066, Free PMC Article
    2. E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters. Kosugi S, et al. Plant J, 2002 Jan. PMID 12060226
    3. The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis. del Pozo JC, et al. Plant Cell, 2006 Sep. PMID 16920782, Free PMC Article
    4. Characterization of two distinct DP-related genes from Arabidopsis thaliana. Magyar Z, et al. FEBS Lett, 2000 Dec 1. PMID 11108847
    5. Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation. Kosugi S, et al. Plant Physiol, 2002 Mar. PMID 11891240, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of E2FC with DPB is a key factor in controlling the balance between cell proliferation and the switch to the endocycle program.
      Title: The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203285.1
    NM_180426.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor DP
    NP_001190214.1
    • DPB; CONTAINS InterPro DOMAIN/s: Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), Transcription factor DP, C-terminal (InterPro:IPR014889), Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor DP (InterPro:IPR015648), Transcription factor DP, subgroup (InterPro:IPR016556); BEST Arabidopsis thaliana protein match is: Transcription factor DP (TAIR:AT5G02470.3).
    NP_850757.1
    • DPB; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), Transcription factor DP, C-terminal (InterPro:IPR014889), Transcription factor DP (InterPro:IPR015648), Transcription factor DP, subgroup (InterPro:IPR016556); BEST Arabidopsis thaliana protein match is: Transcription factor DP (TAIR:AT5G02470.3); Has 509 Blast hits to 501 proteins in 101 species: Archae - 0; Bacteria - 0; Metazoa - 249; Fungi - 7; Plants - 91; Viruses - 0; Other Eukaryotes - 162 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      842289..845454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203285.1 → NP_001190214.1  Transcription factor DP [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UIJ9, A0A5S9Y1U8
      Conserved Domains (4) summary
      cd14458
      Location:181 → 227
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:103 → 176
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam06567
      Location:270 → 314
      Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
      pfam08781
      Location:183 → 289
      DP; Transcription factor DP

    2. NM_180426.3 → NP_850757.1  Transcription factor DP [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDG3, Q9FNY2, Q9LZE7
      UniProtKB/TrEMBL
      A0A178UIJ9, A0A5S9Y1U8
      Conserved Domains (4) summary
      cd14458
      Location:187 → 233
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:101 → 182
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam06567
      Location:276 → 320
      Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
      pfam08781
      Location:189 → 295
      DP; Transcription factor DP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNY2.1

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