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    PDK1 3'-phosphoinositide-dependent protein kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830330, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDK1
    Official Full Name
    3'-phosphoinositide-dependent protein kinase 1
    Primary source
    TAIR:AT5G04510
    Locus tag
    AT5G04510
    See related
    Araport:AT5G04510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3'-phosphoinositide-dependent protein kinase 1; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1; ATPDK1; T32M21.110; T32M21_110
    Summary
    Encodes 3-phosphoinositide-dependent protein kinase that contains pleckstrin homology domain and binds 3-phosphoinositides. It activates the protein kinase AGC2-1 in a phosphatidic acid dependent manner. Phosphorylates S6K1. Interacts with PID, and transphosphorylation by PDK1 increases PID autophosphorylation.
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    Genomic context

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    See PDK1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (1286843..1289908)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene phytol kinase 1 VTE5 Neighboring gene glycosyltransferase family protein 47 Neighboring gene 3-oxoacyl-acyl-carrier synthase-like protein (Protein of unknown function DUF455) Neighboring gene 3-ketoacyl-CoA synthase 19 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lipid code-dependent phosphoswitch PDK1-D6PK activates PIN-mediated auxin efflux in Arabidopsis. Tan S, et al. Nat Plants, 2020 May. PMID 32393881
    2. Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain. Deak M, et al. FEBS Lett, 1999 May 28. PMID 10371193
    3. Arabidopsis PDK1: identification of sites important for activity and downstream phosphorylation of S6 kinase. Otterhag L, et al. Biochimie, 2006 Jan. PMID 16125835
    4. PDK1 regulates auxin transport and Arabidopsis vascular development through AGC1 kinase PAX. Xiao Y, et al. Nat Plants, 2020 May. PMID 32393878
    5. Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis. Zegzouti H, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16601102, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mRNA surveillance complex PELOTA-HBS1 regulates phosphoinositide-dependent protein kinase1 and plant growth.
      Title: mRNA surveillance complex PELOTA-HBS1 regulates phosphoinositide-dependent protein kinase1 and plant growth.
    2. The lipid code-dependent phosphoswitch PDK1-D6PK activates PIN-mediated auxin efflux in Arabidopsis.
      Title: The lipid code-dependent phosphoswitch PDK1-D6PK activates PIN-mediated auxin efflux in Arabidopsis.
    3. PDK1 regulates auxin transport and Arabidopsis vascular development through AGC1 kinase PAX.
      Title: PDK1 regulates auxin transport and Arabidopsis vascular development through AGC1 kinase PAX.
    4. Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
      Title: The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis.
    5. PDK1 is a potent enhancer of PID activity.
      Title: Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis.
    6. PDK1 undergoes autophosphorylation at several sites; mutation of Ser-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp-167, Thr-176, & Thr-211
      Title: Arabidopsis PDK1: identification of sites important for activity and downstream phosphorylation of S6 kinase.
    7. specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
      Title: The Arabidopsis protein kinase PTI1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342779.1
    NM_120533.5
    NM_203001.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    3'-phosphoinositide-dependent protein kinase 1
    NP_568138.1
    • 3'-phosphoinositide-dependent protein kinase 1 (PDK1); FUNCTIONS IN: 3-phosphoinositide-dependent protein kinase activity, protein binding, phosphoinositide binding, protein kinase activity, kinase activity; INVOLVED IN: positive regulation of protein kinase activity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Serine/threonine-protein kinase-1, 3-phosphoinositide dependent (InterPro:IPR015746), Protein kinase, catalytic domain (InterPro:IPR000719), Pleckstrin homology-type (InterPro:IPR011993); BEST Arabidopsis thaliana protein match is: 3-phosphoinositide-dependent protein kinase (TAIR:AT3G10540.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974730.1
    • 3'-phosphoinositide-dependent protein kinase 1 (PDK1); FUNCTIONS IN: 3-phosphoinositide-dependent protein kinase activity, protein binding, phosphoinositide binding, protein kinase activity, kinase activity; INVOLVED IN: positive regulation of protein kinase activity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase-1, 3-phosphoinositide dependent (InterPro:IPR015746), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: 3-phosphoinositide-dependent protein kinase (TAIR:AT3G10540.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1286843..1289908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_203001.4 → NP_974730.1  3'-phosphoinositide-dependent protein kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JWB0
      Conserved Domains (2) summary
      smart00220
      Location:44 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05581
      Location:42 → 311
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    2. NM_120533.5 → NP_568138.1  3'-phosphoinositide-dependent protein kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LZ74, Q9XF67
      UniProtKB/TrEMBL
      A0A5S9Y273, A0A654FY69
      Conserved Domains (2) summary
      cd05581
      Location:42 → 311
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
      pfam14593
      Location:388 → 490
      PH_3; PH domain

    3. NM_001342779.1 → NP_001330324.1  3'-phosphoinositide-dependent protein kinase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BAG1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XF67.1

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