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    YUC4 Flavin-binding monooxygenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831003, updated on 18-Sep-2024

    Summary

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    Official Symbol
    YUC4
    Official Full Name
    Flavin-binding monooxygenase family protein
    Primary source
    TAIR:AT5G11320
    Locus tag
    AT5G11320
    See related
    Araport:AT5G11320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtYUC4; F2I11.210; F2I11_210; YUCCA4
    Summary
    Belongs to the YUC gene family. Encodes a predicted flavin monooxygenase YUC4 involved in auxin biosynthesis and plant development.
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    Genomic context

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    See YUC4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (3611247..3613640, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene mitotic-like cyclin 3B from Arabidopsi Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene tRNA-Gly Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of the auxin biosynthesis gene YUCCA4 determines its subcellular compartmentation. Kriechbaumer V, et al. Plant J, 2012 Apr. PMID 22233288
    2. FUSCA3 interacting with LEAFY COTYLEDON2 controls lateral root formation through regulating YUCCA4 gene expression in Arabidopsis thaliana. Tang LP, et al. New Phytol, 2017 Mar. PMID 27878992
    3. YUCCA genes are expressed in response to leaf adaxial-abaxial juxtaposition and are required for leaf margin development. Wang W, et al. Plant Physiol, 2011 Dec. PMID 22003085, Free PMC Article
    4. Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy. Yamaguchi N, et al. Nat Commun, 2018 Dec 11. PMID 30538233, Free PMC Article
    5. NPY1, a BTB-NPH3-like protein, plays a critical role in auxin-regulated organogenesis in Arabidopsis. Cheng Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18000043, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The feed-forward YUC4 activation by AG and CRC directs a precise change in chromatin state for the shift from floral stem cell maintenance to gynoecium formation.
      Title: Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy.
    2. LEAFY COTYLEDON2 (LEC2) was identified as an interacting factor of FUS3, and demonstrated that these two homologous B3 transcription factors interact to bind to the auxin biosynthesis gene YUCCA4 (YUC4) and synergistically activate its transcription during lateral roots formation.
      Title: FUSCA3 interacting with LEAFY COTYLEDON2 controls lateral root formation through regulating YUCCA4 gene expression in Arabidopsis thaliana.
    3. Expressions of YUCs in the leaf respond to the adaxial-abaxial juxtaposition, and that the activities of auxin mediate leaf margin development, which subsequently promotes blade outgrowth.
      Title: YUCCA genes are expressed in response to leaf adaxial-abaxial juxtaposition and are required for leaf margin development.
    4. Data show the differential localization of YUCCA4 (At5g11320) alternative splice variants to the endoplasmic reticulum and the cytosol, which depends on tissue-specific splicing.
      Title: Alternative splicing of the auxin biosynthesis gene YUCCA4 determines its subcellular compartmentation.
    Submit: New GeneRIF Correction

    General gene information

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    NM_121170.3
    NM_180477.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables indole-3-pyruvate monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables indolepyruvate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in auxin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within auxin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within floral meristem determinacy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within inflorescence development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phyllome development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of anatomical structure morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Flavin-binding monooxygenase family protein
    NP_196693.1
    • YUCCA4 (YUC4); FUNCTIONS IN: NADP or NADPH binding, oxidoreductase activity, monooxygenase activity, FAD binding, flavin-containing monooxygenase activity; INVOLVED IN: in 7 processes; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: Flavin-binding monooxygenase family protein (TAIR:AT4G32540.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850808.1
    • YUCCA4 (YUC4); FUNCTIONS IN: NADP or NADPH binding, oxidoreductase activity, monooxygenase activity, FAD binding, flavin-containing monooxygenase activity; INVOLVED IN: in 7 processes; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: Flavin-binding monooxygenase family protein (TAIR:AT4G32540.1); Has 12265 Blast hits to 12250 proteins in 1811 species: Archae - 85; Bacteria - 7080; Metazoa - 781; Fungi - 1596; Plants - 658; Viruses - 0; Other Eukaryotes - 2065 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3611247..3613640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121170.3 → NP_196693.1  Flavin-binding monooxygenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E9I6, Q9LFM5
      UniProtKB/TrEMBL
      A0A178UJ31, A0A5S9Y3W9
      Conserved Domains (1) summary
      COG2072
      Location:18 → 386
      CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]

    2. NM_180477.2 → NP_850808.1  Flavin-binding monooxygenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y3W9
      Conserved Domains (2) summary
      pfam13434
      Location:18 → 325
      K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)
      cl21454
      Location:18 → 208
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFM5.1

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