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    EMB1467 NADH-ubiquinone dehydrogenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833729, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EMB1467
    Official Full Name
    NADH-ubiquinone dehydrogenase
    Primary source
    TAIR:AT5G37510
    Locus tag
    AT5G37510
    See related
    Araport:AT5G37510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CI76; embryo defective 1467; MPA22.5; MPA22_5
    Summary
    Encodes a subunit of the 400 kDa subcomplex of the mitochondrial NADH dehydrogenase (complex I). The protein has been isolated in the male gametophyte.
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    Genomic context

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    See EMB1467 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (14897329..14900693)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene gated outwardly-rectifying K+ channel Neighboring gene NEP-interacting protein, putative (DUF239) Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism. König AC, et al. Plant Physiol, 2014 Mar. PMID 24424322, Free PMC Article
    2. Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants. Sunderhaus S, et al. J Biol Chem, 2006 Mar 10. PMID 16407270
    3. Mitochondrial complex I from Arabidopsis and rice: orthologs of mammalian and fungal components coupled with plant-specific subunits. Heazlewood JL, et al. Biochim Biophys Acta, 2003 Jul 10. PMID 12837548
    4. The impact of oxidative stress on Arabidopsis mitochondria. Sweetlove LJ, et al. Plant J, 2002 Dec. PMID 12492832
    5. Internal architecture of mitochondrial complex I from Arabidopsis thaliana. Klodmann J, et al. Plant Cell, 2010 Mar. PMID 20197505, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123110.2
    NM_180772.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within photorespiration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 
    part_of respiratory chain complex I HDA PubMed 
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH-ubiquinone dehydrogenase
    NP_568550.1
    • embryo defective 1467 (EMB1467); FUNCTIONS IN: in 6 functions; INVOLVED IN: response to oxidative stress, photorespiration, embryo development ending in seed dormancy; LOCATED IN: mitochondrion, mitochondrial membrane, chloroplast, mitochondrial respiratory chain complex I, respiratory chain complex I; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding (InterPro:IPR019574), NADH:ubiquinone oxidoreductase, subunit G (InterPro:IPR010228), Molybdopterin oxidoreductase (InterPro:IPR006656), Ferredoxin (InterPro:IPR001041), NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site (InterPro:IPR000283), NADH-quinone oxidoreductase, chain G, C-terminal (InterPro:IPR015405); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_851103.1
    • embryo defective 1467 (EMB1467); FUNCTIONS IN: in 6 functions; INVOLVED IN: response to oxidative stress, photorespiration, embryo development ending in seed dormancy; LOCATED IN: mitochondrion, mitochondrial membrane, chloroplast, mitochondrial respiratory chain complex I, respiratory chain complex I; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding (InterPro:IPR019574), NADH:ubiquinone oxidoreductase, subunit G (InterPro:IPR010228), Molybdopterin oxidoreductase (InterPro:IPR006656), Ferredoxin (InterPro:IPR001041), NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site (InterPro:IPR000283), NADH-quinone oxidoreductase, chain G, C-terminal (InterPro:IPR015405); Has 12426 Blast hits to 11022 proteins in 2097 species: Archae - 340; Bacteria - 6853; Metazoa - 215; Fungi - 114; Plants - 76; Viruses - 0; Other Eukaryotes - 4828 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      14897329..14900693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180772.2 → NP_851103.1  NADH-ubiquinone dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK51, B9DFQ9
      Conserved Domains (5) summary
      PRK09130
      Location:74 → 743
      PRK09130; NADH dehydrogenase subunit G; Validated
      cd02773
      Location:291 → 664
      MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
      pfam09326
      Location:703 → 738
      NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
      pfam10588
      Location:155 → 194
      NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
      pfam13510
      Location:71 → 149
      Fer2_4; 2Fe-2S iron-sulfur cluster binding domain

    2. NM_123110.2 → NP_568550.1  NADH-ubiquinone dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940B1, Q9FGI6
      UniProtKB/TrEMBL
      A0A7G2FGL7
      Conserved Domains (1) summary
      PRK09130
      Location:74 → 743
      PRK09130; NADH dehydrogenase subunit G; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGI6.2

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