MYB23 myb domain protein 23 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MYB23
Official Full Name: myb domain protein 23
Primary source: TAIR:AT5G40330
Locus tag: AT5G40330
See related: Araport:AT5G40330
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMYB23; ATMYBRTF; MPO12.40; MPO12_40; myb domain protein 23; MYB DOMAIN PROTEIN 23
Summary: Encodes a MYB gene that, when overexpressed ectopically, can induce ectopic trichome formation. It is a member of subgroup 15, together with WER and GL1. Members of this subgroup share a conserved motif of 19 amino acids in the putative transcription activation domain at the C-terminal end. The gene is expressed in leaves, stems, flowers, seeds and roots and quite strongly in trichomes. There is partial functional redundancy between ATMYB23 and GL1. The two proteins are functionally equivalent with respect to the regulation of trichome initiation but not with respect to trichome branching - which is controlled by MYB23 and not GL1.
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Genomic context

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See MYB23 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (16127725..16129661)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Basis for a Cell Fate Switch in Response to Impaired Ribosome Biogenesis in the Arabidopsis Root Epidermis.
Title: Molecular Basis for a Cell Fate Switch in Response to Impaired Ribosome Biogenesis in the Arabidopsis Root Epidermis.
MYB23 acquired a specific function for trichome differentiation during evolution.
Title: Functional divergence of MYB-related genes, WEREWOLF and AtMYB23 in Arabidopsis.
MYB23 showed a pattern of low expression in pavement cells, medium in basal cells and high expression in trichomes.
Title: Quantitative expression analysis of selected transcription factors in pavement, basal and trichome cells of mature leaves from Arabidopsis thaliana.
MYB23 participates in a positive feedback loop to reinforce cell fate decisions and ensure robust establishment of the cell type pattern in the Arabidopsis root epidermis.
Title: The MYB23 gene provides a positive feedback loop for cell fate specification in the Arabidopsis root epidermis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_123397.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within root epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome patterning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: myb domain protein 23

NP_198849.1

myb domain protein 23 (MYB23); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 0 (TAIR:AT3G27920.1); Has 9054 Blast hits to 8348 proteins in 517 species: Archae - 0; Bacteria - 0; Metazoa - 771; Fungi - 507; Plants - 5936; Viruses - 3; Other Eukaryotes - 1837 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16127725..16129661

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123397.3 → NP_198849.1 myb domain protein 23 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198849.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49760, Q96276

UniProtKB/TrEMBL

A0A178UNZ5, A0A5S9Y9J4

Conserved Domains (1) summary

PLN03212
Location:13 → 116

PLN03212; Transcription repressor MYB5; Provisional