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    Mfl1 Mitochondrial substrate carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834218, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Mfl1
    Official Full Name
    Mitochondrial substrate carrier family protein
    Primary source
    TAIR:AT5G42130
    Locus tag
    AT5G42130
    See related
    Araport:AT5G42130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMfl1; MitoFerrinLike1; MJC20.24; MJC20_24
    Summary
    Encodes a protein belonging to the mitochondrial carrier family and similar to animal mitoferrin but likely NOT to be located in the mitochondria, but rather in chloroplasts. It is likely to be involved in transporting iron into the chloroplast.
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    Genomic context

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    See Mfl1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (16835233..16836895, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an Arabidopsis mitoferrinlike carrier protein involved in Fe metabolism. Tarantino D, et al. Plant Physiol Biochem, 2011 May. PMID 21371898
    2. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    3. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At5g42130 gene expression correlates with the expression of genes involved in chloroplast Fe metabolism.
      Title: Identification of an Arabidopsis mitoferrinlike carrier protein involved in Fe metabolism.
    Submit: New GeneRIF Correction

    General gene information

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    NM_123578.4

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Mitochondrial substrate carrier family protein
    NP_199028.1
    • Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding; INVOLVED IN: transport, mitochondrial transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: S-adenosylmethionine carrier 2 (TAIR:AT1G34065.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16835233..16836895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123578.4 → NP_199028.1  Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199028.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FHX2
      UniProtKB/TrEMBL
      A0A178U9Z1, A0A5S9YA75
      Conserved Domains (1) summary
      PTZ00168
      Location:132 → 384
      PTZ00168; mitochondrial carrier protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FHX2.1

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