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    PKT3 peroxisomal 3-ketoacyl-CoA thiolase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817876, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PKT3
    Official Full Name
    peroxisomal 3-ketoacyl-CoA thiolase 3
    Primary source
    TAIR:AT2G33150
    Locus tag
    AT2G33150
    See related
    Araport:AT2G33150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-KETOACYL-COA THIOLASE 2; KAT2; PED1; peroxisomal 3-ketoacyl-CoA thiolase 3; PEROXISOME DEFECTIVE 1; potassium channel in Arabidopsis thaliana 2
    Summary
    Encodes an organellar (peroxisome, glyoxysome) 3-ketoacyl-CoA thiolase, involved in fatty acid b-oxidation during germination and subsequent seedling growth. Mutants have defects in glyoxysomal fatty acid beta-oxidation. EC2.3.1.16 thiolase.
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    Genomic context

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    See PKT3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (14047478..14051400, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ralf-like 18 Neighboring gene tRNA-Met Neighboring gene glycoside hydrolase family 28 protein / polygalacturonase (pectinase) family protein Neighboring gene Leucine-rich repeat receptor-like protein kinase family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the beta-oxidation gene 3-ketoacyl-CoA thiolase 2 (KAT2) is required for the timely onset of natural and dark-induced leaf senescence in Arabidopsis. Castillo MC, et al. J Exp Bot, 2008. PMID 18441338, Free PMC Article
    2. 2,4-Dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation. Hayashi M, et al. Plant Cell, 1998 Feb. PMID 9490742, Free PMC Article
    3. Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Germain V, et al. Plant J, 2001 Oct. PMID 11696182
    4. The Arabidopsis 3-ketoacyl-CoA thiolase-2 (kat2-1) mutant exhibits increased flowering but reduced reproductive success. Footitt S, et al. J Exp Bot, 2007. PMID 17728299
    5. Novel proteins, putative membrane transporters, and an integrated metabolic network are revealed by quantitative proteomic analysis of Arabidopsis cell culture peroxisomes. Eubel H, et al. Plant Physiol, 2008 Dec. PMID 18931141, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxisomal KAT2 and KAT5 have partially redundant functions and operate downstream of AIM1 to provide beta-oxidation functions essential for inflorescence development and fertility.
      Title: Knockout of the two evolutionarily conserved peroxisomal 3-ketoacyl-CoA thiolases in Arabidopsis recapitulates the abnormal inflorescence meristem 1 phenotype.
    2. KAT2 as an essential component for the timely onset of leaf senescence in Arabidopsis.
      Title: Expression of the beta-oxidation gene 3-ketoacyl-CoA thiolase 2 (KAT2) is required for the timely onset of natural and dark-induced leaf senescence in Arabidopsis.
    3. Mutations within the 3-ketoacyl-CoA thiolase 2 (KAT2) gene interferes with the balance between silique development and the continued initiation of floral meristems. [KAT2]
      Title: The Arabidopsis 3-ketoacyl-CoA thiolase-2 (kat2-1) mutant exhibits increased flowering but reduced reproductive success.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128874.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA C-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA C-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetyl-CoA C-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid oxidation TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within glyoxysome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    peroxisomal 3-ketoacyl-CoA thiolase 3
    NP_180873.1
    • peroxisomal 3-ketoacyl-CoA thiolase 3 (PKT3); FUNCTIONS IN: acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid beta-oxidation, jasmonic acid biosynthetic process, response to wounding, fatty acid oxidation, glyoxysome organization; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 4 (TAIR:AT1G04710.1); Has 22382 Blast hits to 22371 proteins in 2261 species: Archae - 414; Bacteria - 14116; Metazoa - 985; Fungi - 655; Plants - 282; Viruses - 0; Other Eukaryotes - 5930 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14047478..14051400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128874.4 → NP_180873.1  peroxisomal 3-ketoacyl-CoA thiolase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WD9, Q93Z35, Q9S7M3
      UniProtKB/TrEMBL
      A0A178VRP9, A0A5S9X3F2
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 456
      PLN02287; 3-ketoacyl-CoA thiolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56WD9.2

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