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    ATSAC1 Phosphoinositide phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838868, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATSAC1
    Official Full Name
    Phosphoinositide phosphatase family protein
    Primary source
    TAIR:AT1G22620
    Locus tag
    AT1G22620
    See related
    Araport:AT1G22620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12K8.3; SAC1; suppressor of actin 1
    Summary
    SAC domain phosphoinositide (3,5)P2 phosphatase. Colocalized with a Golgi Marker. Required for normal cell morphogenesis, cell wall synthesis, and actin organization.
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    Genomic context

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    See ATSAC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (7994166..8002989, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like 87 Neighboring gene Late embryogenesis abundant protein (LEA) family protein Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein Neighboring gene SSUH2-like protein Neighboring gene myb domain protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of SAC1, an Arabidopsis SAC domain phosphoinositide phosphatase, causes alterations in cell morphogenesis, cell wall synthesis, and actin organization. Zhong R, et al. Plant Cell, 2005 May. PMID 15805481, Free PMC Article
    2. Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P Phosphoinositide Are Key Host Factors during the Biogenesis of the Tombusvirus Replication Compartment. Sasvari Z, et al. J Virol, 2020 Jun 1. PMID 32269127, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P Phosphoinositide Are Key Host Factors during the Biogenesis of the Tombusvirus Replication Compartment.
      Title: Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P Phosphoinositide Are Key Host Factors during the Biogenesis of the Tombusvirus Replication Compartment.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_102109.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Phosphoinositide phosphatase family protein
    NP_173676.2
    • suppressor of actin 1 (ATSAC1); CONTAINS InterPro DOMAIN/s: Synaptojanin, N-terminal (InterPro:IPR002013); BEST Arabidopsis thaliana protein match is: Phosphoinositide phosphatase family protein (TAIR:AT3G14205.1); Has 2374 Blast hits to 1664 proteins in 228 species: Archae - 0; Bacteria - 0; Metazoa - 925; Fungi - 777; Plants - 320; Viruses - 0; Other Eukaryotes - 352 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7994166..8002989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102109.4 → NP_173676.2  Phosphoinositide phosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173676.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80557, Q7XZU3, Q9SKA4
      UniProtKB/TrEMBL
      A0A178WK36, A0A5S9VJK3
      Conserved Domains (1) summary
      pfam02383
      Location:109 → 407
      Syja_N; SacI homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XZU3.1

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