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    ELP2 elongator protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841378, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ELP2
    Official Full Name
    elongator protein 2
    Primary source
    TAIR:AT1G49540
    Locus tag
    AT1G49540
    See related
    Araport:AT1G49540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtELP2; elongator protein 2; Elongator subunit 2; F14J22.24
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    Genomic context

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    See ELP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (18333623..18337520, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene SWIB complex BAF60b domain-containing protein Neighboring gene ncRNA Neighboring gene geranylgeranyl pyrophosphate synthase 6 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Homeodomain-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Elongator subunit 2 positively contributes to resistance to the necrotrophic fungal pathogens Botrytis cinerea and Alternaria brassicicola. Wang C, et al. Plant J, 2015 Sep. PMID 26216741
    2. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. Jia Y, et al. J Exp Bot, 2015 Aug. PMID 25998905, Free PMC Article
    3. The Arabidopsis elongator complex subunit2 epigenetically regulates plant immune responses. Wang Y, et al. Plant Cell, 2013 Feb. PMID 23435660, Free PMC Article
    4. Elongator subunit 2 is an accelerator of immune responses in Arabidopsis thaliana. DeFraia CT, et al. Plant J, 2010 Nov. PMID 20807211
    5. Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis. Zhou X, et al. Plant J, 2009 Oct. PMID 19500300

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELP2 positively contributes to resistance to the necrotrophic fungal pathogens Botrytis cinerea and Alternaria brassicicola.
      Title: Arabidopsis Elongator subunit 2 positively contributes to resistance to the necrotrophic fungal pathogens Botrytis cinerea and Alternaria brassicicola.
    2. The elp2 mutant had accelerated differentiation of root stem cells and cell division was more active in its quiescent centre (QC); the key transcription factors responsible for maintaining root stem cell and QC identity were all strongly down-regulated.
      Title: The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development.
    3. ELP2 plays an evolutionarily conserved role in DNA demethylation/methylation in plants and likely functions as an epigenetic regulator of plant immune responses.
      Title: The Arabidopsis elongator complex subunit2 epigenetically regulates plant immune responses.
    4. AtELP2 is an accelerator of defense gene induction, which functions largely independently of NPR1 in establishing plant immunity.
      Title: Elongator subunit 2 is an accelerator of immune responses in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001198251.2
    NM_103842.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of anthocyanin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    elongator protein 2
    NP_001185180.1
    • elongator protein 2 (ELP2); FUNCTIONS IN: nucleotide binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1).
    NP_175377.2
    • elongator protein 2 (ELP2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1); Has 20963 Blast hits to 10648 proteins in 489 species: Archae - 20; Bacteria - 4818; Metazoa - 7110; Fungi - 4617; Plants - 1726; Viruses - 0; Other Eukaryotes - 2672 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18333623..18337520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198251.2 → NP_001185180.1  elongator protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WNF9, A0A654EM27, F4I1S8
      Conserved Domains (3) summary
      COG2319
      Location:69 → 502
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:651 → 694
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:54 → 443
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_103842.3 → NP_175377.2  elongator protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175377.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I1S7, O22044, Q0WVT2, Q9XIC1
      UniProtKB/TrEMBL
      A0A7G2E1J5
      Conserved Domains (3) summary
      COG2319
      Location:69 → 500
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:649 → 692
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:54 → 441
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I1S7.1

    Gene LinkOut

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