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    GAD2 glutamate decarboxylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842908, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAD2
    Official Full Name
    glutamate decarboxylase 2
    Primary source
    TAIR:AT1G65960
    Locus tag
    AT1G65960
    See related
    Araport:AT1G65960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12P19.12; F12P19_12; glutamate decarboxylase 2; GLUTAMATE DECARBOXYLASE 2
    Summary
    glutamate decarboxylase (GAD2)
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    Genomic context

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    See GAD2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (24551807..24557730)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene thioredoxin-dependent peroxidase 2 Neighboring gene thioredoxin-dependent peroxidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two glutamate decarboxylase cDNA clones from Arabidopsis. Turano FJ, et al. Plant Physiol, 1998 Aug. PMID 9701597, Free PMC Article
    2. GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience. Xu B, et al. Nat Commun, 2021 Mar 29. PMID 33782393, Free PMC Article
    3. Two isoforms of glutamate decarboxylase in Arabidopsis are regulated by calcium/calmodulin and differ in organ distribution. Zik M, et al. Plant Mol Biol, 1998 Aug. PMID 9700069
    4. Genes encoding calmodulin-binding proteins in the Arabidopsis genome. Reddy VS, et al. J Biol Chem, 2002 Mar 22. PMID 11782485
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience.
      Title: GABA signalling modulates stomatal opening to enhance plant water use efficiency and drought resilience.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001124084.1
    NM_001334228.1
    NM_001334229.1
    NM_105268.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables glutamate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutamate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glutamate decarboxylase 2
    NP_001117556.1
    • glutamate decarboxylase 2 (GAD2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Glutamate decarboxylase (InterPro:IPR010107), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: glutamate decarboxylase (TAIR:AT5G17330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001319328.1
    • glutamate decarboxylase 2 (GAD2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent decarboxylase (InterPro:IPR002129), Glutamate decarboxylase (InterPro:IPR010107), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: glutamate decarboxylase (TAIR:AT5G17330.1); Has 2686 Blast hits to 2683 proteins in 834 species: Archae - 189; Bacteria - 1522; Metazoa - 142; Fungi - 352; Plants - 304; Viruses - 2; Other Eukaryotes - 175 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24551807..24557730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334228.1 → NP_001319328.1  glutamate decarboxylase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q56W28

    2. NM_001334229.1 → NP_001320515.1  glutamate decarboxylase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q56W28

    3. NM_001124084.1 → NP_001117556.1  glutamate decarboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42472, Q8RXH0, Q944L6
      UniProtKB/TrEMBL
      A0A178WE81, A0A5S9WSI3, A0A7G2E4E0
      Conserved Domains (1) summary
      TIGR01788
      Location:17 → 444
      Glu-decarb-GAD; glutamate decarboxylase

    4. NM_105268.7 → NP_176771.2  glutamate decarboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176771.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q56W28
      Conserved Domains (1) summary
      cl18945
      Location:1 → 315
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42472.1

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