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    GA3OX2 gibberellin 3-oxidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844374, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GA3OX2
    Official Full Name
    gibberellin 3-oxidase 2
    Primary source
    TAIR:AT1G80340
    Locus tag
    AT1G80340
    See related
    Araport:AT1G80340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GIBBERELLIN-3-OXIDASE 2; ATGA3OX2; F5I6.9; F5I6_9; GA4H; GIBBERELLIN 3 BETA-HYDROXYLASE; gibberellin 3-oxidase 2
    Summary
    Encodes a protein with gibberellin 3 beta-hydroxylase activity. The protein was heterologously expressed in E. coli and shown to catalyze the hydroxylation of both GA9 and GA20.
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    Genomic context

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    See GA3OX2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (30200466..30202349, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene gibberellin 3-oxidase 4 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phytochrome regulation and differential expression of gibberellin 3beta-hydroxylase genes in germinating Arabidopsis seeds. Yamaguchi S, et al. Plant Cell, 1998 Dec. PMID 9836749, Free PMC Article
    2. [Molecular mechanism of AtGA3OX1 and AtGA3OX2 genes affecting secondary wall thickening in stems in Arabidopsis]. Wang ZG, et al. Yi Chuan, 2013 May. PMID 23732673
    3. AtGA3ox2, a key gene responsible for bioactive gibberellin biosynthesis, is regulated during embryogenesis by LEAFY COTYLEDON2 and FUSCA3 in Arabidopsis. Curaba J, et al. Plant Physiol, 2004 Nov. PMID 15516508, Free PMC Article
    4. The involvement of gibberellin 20-oxidase genes in phytochrome-regulated petiole elongation of Arabidopsis. Hisamatsu T, et al. Plant Physiol, 2005 Jun. PMID 15923331, Free PMC Article
    5. Regulation of hormone metabolism in Arabidopsis seeds: phytochrome regulation of abscisic acid metabolism and abscisic acid regulation of gibberellin metabolism. Seo M, et al. Plant J, 2006 Nov. PMID 17010113

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of GA3OX1 and GA3OX2 genes resulted in reduction of secondary wall thickening of fiber cells.
      Title: [Molecular mechanism of AtGA3OX1 and AtGA3OX2 genes affecting secondary wall thickening in stems in Arabidopsis].
    2. The GA-biosynthesis gene AtGA3ox2, which encodes the key enzyme AtGA3ox2 that catalyzes the conversion of inactive to bioactive gibberellins, is ectopically activated in embryos of the lec2 and fus3 mutants. [AtGA3ox2]
      Title: AtGA3ox2, a key gene responsible for bioactive gibberellin biosynthesis, is regulated during embryogenesis by LEAFY COTYLEDON2 and FUSCA3 in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gibberellin 3-beta-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gibberellin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gibberellin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gibberellin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red or far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    gibberellin 3-oxidase 2
    NP_178150.1
    • gibberellin 3-oxidase 2 (GA3OX2); CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: gibberellin 3-oxidase 1 (TAIR:AT1G15550.1); Has 8474 Blast hits to 8441 proteins in 992 species: Archae - 0; Bacteria - 1121; Metazoa - 111; Fungi - 981; Plants - 4917; Viruses - 0; Other Eukaryotes - 1344 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30200466..30202349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106683.2 → NP_178150.1  gibberellin 3-oxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C970, Q9ZT84
      UniProtKB/TrEMBL
      A0A178W4I4, A0A654ES55, A0A7G2E4E6
      Conserved Domains (1) summary
      PLN02254
      Location:1 → 347
      PLN02254; gibberellin 3-beta-dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZT84.2

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