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    LRS1 Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819671, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LRS1
    Official Full Name
    Transducin/WD40 repeat-like superfamily protein
    Primary source
    TAIR:AT3G05090
    Locus tag
    AT3G05090
    See related
    Araport:AT3G05090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LATERAL ROOT STIMULATOR 1; T12H1.5; T12H1_5
    Summary
    Encodes a DCAF protein. Mutants are defective in lateral root development and suggest roles for DDB1##Cul4#Aeimediated protein degradation in regulating auxin accumulation during lateral root primordium development and lateral root meristem emergence.
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    Genomic context

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    See LRS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Sequence:
    Chromosome: 3; NC_003074.8 (1417893..1423673, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NOP56-like pre RNA processing ribonucleoprotein Neighboring gene Cwf18 pre-mRNA splicing factor Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene early endosome antigen-like protein, putative (DUF3444) Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana. Lee I, et al. Nat Biotechnol, 2010 Feb. PMID 20118918, Free PMC Article
    2. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    3. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article
    4. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337562.1
    NM_111381.3
    NM_180185.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin/WD40 repeat-like superfamily protein
    NP_566246.1
    • LATERAL ROOT STIMULATOR 1 (LRS1); FUNCTIONS IN: nucleotide binding; INVOLVED IN: lateral root formation; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Protein of unknown function DUF3337 (InterPro:IPR021772), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Coatomer, alpha subunit (TAIR:AT1G62020.1); Has 59803 Blast hits to 26869 proteins in 729 species: Archae - 50; Bacteria - 7042; Metazoa - 23770; Fungi - 14096; Plants - 7202; Viruses - 3; Other Eukaryotes - 7640 (source: NCBI BLink).
    NP_850516.1
    • LATERAL ROOT STIMULATOR 1 (LRS1); FUNCTIONS IN: nucleotide binding; INVOLVED IN: lateral root formation; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Protein of unknown function DUF3337 (InterPro:IPR021772), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Coatomer, alpha subunit (TAIR:AT1G62020.1); Has 59803 Blast hits to 26869 proteins in 729 species: Archae - 50; Bacteria - 7042; Metazoa - 23770; Fungi - 14096; Plants - 7202; Viruses - 3; Other Eukaryotes - 7640 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1417893..1423673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180185.3 → NP_850516.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V6P1, A0A384LLQ1, A0A5S9X9A8, Q93ZS6
      Conserved Domains (3) summary
      cd00200
      Location:34 → 323
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:88 → 124
      7WD40; WD40 repeat [structural motif]
      cd17041
      Location:626 → 748
      Ubl_WDR48; Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins

    2. NM_111381.3 → NP_566246.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V6P1, A0A384LLQ1, A0A5S9X9A8, Q93ZS6
      Conserved Domains (3) summary
      cd00200
      Location:34 → 323
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:88 → 124
      7WD40; WD40 repeat [structural motif]
      cd17041
      Location:626 → 748
      Ubl_WDR48; Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins

    3. NM_001337562.1 → NP_001325515.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V6P1, A0A384LLQ1, A0A5S9X9A8, Q93ZS6
      Conserved Domains (3) summary
      cd00200
      Location:34 → 323
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:88 → 124
      7WD40; WD40 repeat [structural motif]
      cd17041
      Location:626 → 748
      Ubl_WDR48; Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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