U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FBL17 RNI-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824630, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FBL17
    Official Full Name
    RNI-like superfamily protein
    Primary source
    TAIR:AT3G54650
    Locus tag
    AT3G54650
    See related
    Araport:AT3G54650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FBL17 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (20225730..20229214, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene kinetochore protein Neighboring gene tryptophan synthase alpha chain Neighboring gene glutathione reductase Neighboring gene Structural maintenance of chromosomes (SMC) family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17. Noir S, et al. Plant Cell, 2015 May. PMID 25944099, Free PMC Article
    2. The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites. Gentric N, et al. Plant Physiol, 2020 Jul. PMID 32414898, Free PMC Article
    3. The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development. Gusti A, et al. PLoS One, 2009. PMID 19277118, Free PMC Article
    4. A novel WEE1 pathway for replication stress responses. Pan T, et al. Nat Plants, 2021 Feb. PMID 33574575
    5. Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors. Kim HJ, et al. Nature, 2008 Oct 23. PMID 18948957

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites.
      Title: The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites.
    2. F-box protein FBL17 acts as a master cell cycle regulator during the diploid sporophyte phase of the plant.
      Title: The Control of Arabidopsis thaliana Growth by Cell Proliferation and Endoreplication Requires the F-Box Protein FBL17.
    3. FBL17 is involved in cell cycle regulation during male gametogenesis. Loss-of-function mutants fail to undergo pollen mitosis II.
      Title: The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_115322.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within generative cell mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    RNI-like superfamily protein
    NP_567005.2
    • FBL17; FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: generative cell mitosis, seed development, embryo development, ubiquitin-dependent protein catabolic process, pollen development; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810); Has 1738 Blast hits to 1195 proteins in 149 species: Archae - 0; Bacteria - 27; Metazoa - 733; Fungi - 89; Plants - 663; Viruses - 0; Other Eukaryotes - 226 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20225730..20229214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115322.4 → NP_567005.2  RNI-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567005.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W104, Q9M1T4
      UniProtKB/TrEMBL
      A0A5S9XKU1, A0A654FGM5
      Conserved Domains (2) summary
      cd09293
      Location:292 → 437
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:199 → 224
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W104.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools