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    MET18 ARM repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834864, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MET18
    Official Full Name
    ARM repeat superfamily protein
    Primary source
    TAIR:AT5G48120
    Locus tag
    AT5G48120
    See related
    Araport:AT5G48120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homolog of yeast MET18; MDN11.21; MDN11_21
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    Genomic context

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    See MET18 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Sequence:
    Chromosome: 5; NC_003076.8 (19507397..19514895, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Terpenoid cyclases/Protein prenyltransferases superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene Pectin lyase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation. Wang X, et al. Sci Rep, 2016 May 19. PMID 27193999, Free PMC Article
    2. MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis. Duan CG, et al. PLoS Genet, 2015 Oct. PMID 26492035, Free PMC Article
    3. The Cytosolic Iron-Sulfur Cluster Assembly Protein MMS19 Regulates Transcriptional Gene Silencing, DNA Repair, and Flowering Time in Arabidopsis. Han YF, et al. PLoS One, 2015. PMID 26053632, Free PMC Article
    4. Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway. Iñigo S, et al. Plant Physiol, 2016 Oct. PMID 27503603, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reveals that MET18 mutation caused DNA hypermethylation at more than 1000 loci, of which about 70% were overlapped with the ROS1 targeted loci, indicating a same genetic pathway. Results show that MET18 regulates active DNA demethylation by affecting the enzymatic activity of the ROS1/DME family proteins. Thus, MET18 can regulate both active DNA demethylation and DNA methylation pathways in Arabidopsis.
      Title: The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation.
    2. Our results suggest that ROS1-mediated active DNA demethylation requires MET18-dependent transfer of the iron-sulfur cluster, highlighting an important role of the CIA pathway in epigenetic regulation. [MET18]
      Title: MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344759.1
    NM_001344760.1
    NM_124186.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by iron-sulfur cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ARM repeat superfamily protein
    NP_001318759.1
    • ARM repeat superfamily protein; FUNCTIONS IN: binding; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-type fold (InterPro:IPR016024); Has 594 Blast hits to 356 proteins in 168 species: Archae - 0; Bacteria - 0; Metazoa - 252; Fungi - 233; Plants - 48; Viruses - 0; Other Eukaryotes - 61 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19507397..19514895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344759.1 → NP_001318759.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVF8, Q9FI26
      UniProtKB/TrEMBL
      A0A5S9YBZ7

    2. NM_001344760.1 → NP_001330951.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVF8, Q9FI26
      UniProtKB/TrEMBL
      A0A5S9YBZ7

    3. NM_124186.5 → NP_199623.2  ARM repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199623.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVF8, Q9FI26
      UniProtKB/TrEMBL
      A0A5S9YBZ7
      Conserved Domains (1) summary
      pfam14500
      Location:50 → 311
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WVF8.1

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