Stx6 syntaxin 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx6provided by MGI
Official Full Name: syntaxin 6provided by MGI
Primary source: MGI:MGI:1926235
See related: Ensembl:ENSMUSG00000026470 AllianceGenome:MGI:1926235
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310039E05Rik; 2410005I16Rik
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in regulation of protein localization. Acts upstream of or within endosome organization. Located in phagocytic vesicle and trans-Golgi network membrane. Orthologous to human STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 26.2), whole brain E14.5 (RPKM 15.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 66.46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (155034374..155083405)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (155158628..155207567)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.
Title: Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.
Cholesterol modulates distribution of syntaxin 6 in insulin granule membranes.
Title: Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.
a novel mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction probably to stabilize their niche in macrophages
Title: Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.
syntaxin 6 is required for rentry of IRAP from cell surface back into the insulin-responsive complex
Title: Recycling of IRAP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE syntaxin 6 but not the GGA clathrin adaptors.
Syntaxin 6 and Vti1b form a SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha
Title: Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI845861 (e-PCR)
- UniSTS:164133

RH138891 (e-PCR)
- UniSTS:220978

AI415714 (e-PCR)
- UniSTS:178484

BB254250 (e-PCR)
- UniSTS:207231

D1Mit55 (e-PCR), detects polymorphism
- UniSTS:128914

NoName (e-PCR)
- UniSTS:234236

NoName (e-PCR)
- UniSTS:234237

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi vesicle transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytic recycling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle to endosome fusion	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle to endosome fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021433.3 → NP_067408.1 syntaxin-6

See identical proteins and their annotated locations for NP_067408.1

Status: VALIDATED

Source sequence(s)

BM899312, BQ749205, BU613686, CF737112, CJ088919, CN456515, CX220575

Consensus CDS

CCDS35741.1

UniProtKB/Swiss-Prot

Q9D3A1, Q9D729, Q9JKK1

UniProtKB/TrEMBL

Q3UA21

Related

ENSMUSP00000027743.8, ENSMUST00000027743.13

Conserved Domains (2) summary

cd15851
Location:166 → 231

SNARE_Syntaxin6; SNARE motif of syntaxin 6

pfam09177
Location:13 → 103

Syntaxin-6_N; Syntaxin 6, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

155034374..155083405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529766.5 → XP_006529829.1 syntaxin-6 isoform X1

UniProtKB/TrEMBL

Q3UA21

Related

ENSMUSP00000141976.2, ENSMUST00000193059.6

Conserved Domains (2) summary

cd15851
Location:166 → 231

SNARE_Syntaxin6; SNARE motif of syntaxin 6

pfam09177
Location:13 → 103

Syntaxin-6_N; Syntaxin 6, N-terminal
XM_036152546.1 → XP_036008439.1 syntaxin-6 isoform X3

Conserved Domains (1) summary

cd15851
Location:65 → 130

SNARE_Syntaxin6; SNARE motif of syntaxin 6
XM_017321868.3 → XP_017177357.1 syntaxin-6 isoform X2

Conserved Domains (1) summary

cd15851
Location:65 → 130

SNARE_Syntaxin6; SNARE motif of syntaxin 6