Vrk2 vaccinia related kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vrk2provided by MGI
Official Full Name: vaccinia related kinase 2provided by MGI
Primary source: MGI:MGI:1917172
See related: Ensembl:ENSMUSG00000064090 AllianceGenome:MGI:1917172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810003O05Rik
Summary: Enables protein serine/threonine kinase activity. Acts upstream of or within protein autophosphorylation. Located in endoplasmic reticulum; membrane; and nuclear envelope. Is expressed in several structures, including cerebral cortex; dorsal mesogastrium; gonad; hemolymphoid system; and yolk sac. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 6.6), liver E14.5 (RPKM 4.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.3; 11 15.94 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (26421398..26544006, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (26471398..26594012, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.
Title: Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.
VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating IKKbeta in pancreatic cancer.
Title: VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer.
VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release.
Title: VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release.
Novel alternatively-spliced exons of the VRK2 gene in mouse brain and microglial cells.
Title: Novel alternatively-spliced exons of the VRK2 gene in mouse brain and microglial cells.
these results provide new insights into how neuronal HNRNP Q decreases VRK2 mRNA stability and contributes to the prevention of Huntington's disease
Title: HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2.
In VRK2-deficient mice (VRK2(KO)), reduced numbers of presynaptic puncta within microglia were observed. Moreover, the numbers of presynaptic puncta and synapses were abnormally increased in VRK2(KO) mice by the second postnatal week. These differences did not persist into adulthood. Adult VRK2(KO) mice showed behavioral defects in social behaviors, contextual fear memory, and spatial memory.
Title: Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment.
VRK genes play a role during embryonic development of hematopoiesis
Title: Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW554273 (e-PCR)
- UniSTS:185866

AI447698 (e-PCR)
- UniSTS:160076

09.MMHAP36FLC3.seq (e-PCR)
- UniSTS:122974

Vrk2 (e-PCR), detects polymorphism
- UniSTS:265687

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase VRK2

Names: vaccinia virus BIR kinase related kinase 2

NP_001239376.1

EC 2.7.11.1

NP_081536.2

EC 2.7.11.1

XP_006514864.1

EC 2.7.11.1

XP_011242050.1

EC 2.7.11.1

XP_030102151.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252447.1 → NP_001239376.1 serine/threonine-protein kinase VRK2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC083815, AL929272

UniProtKB/Swiss-Prot

Q8BN21

Conserved Domains (2) summary

pfam00069
Location:29 → 292

Pkinase; Protein kinase domain

cl21453
Location:16 → 314

PKc_like; Protein Kinases, catalytic domain
NM_027260.3 → NP_081536.2 serine/threonine-protein kinase VRK2 isoform 1

See identical proteins and their annotated locations for NP_081536.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AF513620, BB852723, BE984366

Consensus CDS

CCDS24486.1

UniProtKB/Swiss-Prot

Q3U415, Q5F1Z5, Q5SP88, Q8BN21, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9

Related

ENSMUSP00000077471.7, ENSMUST00000078362.13

Conserved Domains (1) summary

cl21453
Location:16 → 314

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

26421398..26544006 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514801.5 → XP_006514864.1 serine/threonine-protein kinase VRK2 isoform X1

See identical proteins and their annotated locations for XP_006514864.1

UniProtKB/Swiss-Prot

Q3U415, Q5F1Z5, Q5SP88, Q8BN21, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9

Related

ENSMUSP00000105130.2, ENSMUST00000109504.8

Conserved Domains (1) summary

cl21453
Location:16 → 314

PKc_like; Protein Kinases, catalytic domain
XM_030246291.1 → XP_030102151.1 serine/threonine-protein kinase VRK2 isoform X2

Conserved Domains (2) summary

PTZ00449
Location:182 → 370

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl21453
Location:1 → 196

PKc_like; Protein Kinases, catalytic domain
XM_011243748.3 → XP_011242050.1 serine/threonine-protein kinase VRK2 isoform X2

Conserved Domains (2) summary

PTZ00449
Location:182 → 370

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl21453
Location:1 → 196

PKc_like; Protein Kinases, catalytic domain