Ddit4l DNA-damage-inducible transcript 4-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddit4lprovided by MGI
Official Full Name: DNA-damage-inducible transcript 4-likeprovided by MGI
Primary source: MGI:MGI:1920534
See related: Ensembl:ENSMUSG00000046818 AllianceGenome:MGI:1920534
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: REDD2; Smhs1; RTP801L; 1700037B15Rik; 1700108M02Rik
Summary: Predicted to be involved in negative regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; eye; frenulum; jaw; and reproductive system. Orthologous to human DDIT4L (DNA damage inducible transcript 4 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in genital fat pad adult (RPKM 36.6), ovary adult (RPKM 10.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 63.81 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (137329433..137334093)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (137623672..137628332)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data showed that DDiT4L may be an important transducer of pathological stress to autophagy through mTOR signaling in the heart.
Title: DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.
Axonal injury-induced upregulation of the stress-responsive REDD2 leads to mTOR inhibition triggering early dendritic arbor retraction, neuronal dysfunction and subsequent death of adult retinal neurons.
Title: REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.
IRF-1 physically interacts with REDD2 in the large cytoplasmic protein complex
Title: Interferon regulatory factor-1 (IRF-1) interacts with regulated in development and DNA damage response 2 (REDD2) in the cytoplasm of mouse bone marrow cells.
REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.
Title: REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.
RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions
Title: The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.
SMHS1 was found to be expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to muscle energy metabolism phenotypes.
Title: SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234835

Ddit4l (e-PCR), detects polymorphism
- UniSTS:498342

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA damage-inducible transcript 4-like protein

Names: HIF-1 responsive protein RTP801-like; skeletal muscle hindlimb suspension 1; soleus muscle atrophied after hindlimb suspension protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030143.4 → NP_084419.2 DNA damage-inducible transcript 4-like protein

Status: VALIDATED

Source sequence(s)

AC140486, AK018944

Consensus CDS

CCDS17863.1

UniProtKB/Swiss-Prot

Q8C0Z7, Q8VD49, Q8VHZ5, Q9CQV2

UniProtKB/TrEMBL

B2RVG4

Related

ENSMUSP00000058896.8, ENSMUST00000053855.8

Conserved Domains (1) summary

pfam07809
Location:65 → 183

RTP801_C; RTP801 C-terminal region