Aplnr apelin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aplnrprovided by MGI
Official Full Name: apelin receptorprovided by MGI
Primary source: MGI:MGI:1346086
See related: Ensembl:ENSMUSG00000044338 AllianceGenome:MGI:1346086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APJ; Agtrl1; msr/apj
Summary: Predicted to enable apelin receptor activity. Involved in circulatory system development; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and regulation of gene expression. Acts upstream of or within regulation of gap junction assembly. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84966704..84970267)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (85136360..85139923)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hormonal dependent expression of apelin and apelin receptor in the ovary and uterus of mice.
Title: Hormonal dependent expression of apelin and apelin receptor in the ovary and uterus of mice.
Immunolocalization of apelin receptor (APJ) in mouse seminiferous epithelium.
Title: Immunolocalization of apelin receptor (APJ) in mouse seminiferous epithelium.
Expression of Apelin and Apelin Receptor Protein in the Hypothalamo-Pituitary-Ovarian Axis during the Estrous Cycle of Mice.
Title: Expression of Apelin and Apelin Receptor Protein in the Hypothalamo-Pituitary-Ovarian Axis during the Estrous Cycle of Mice.
ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.
Title: ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.
Postnatal developmental expression of apelin receptor proteins and its role in juvenile mice testis.
Title: Postnatal developmental expression of apelin receptor proteins and its role in juvenile mice testis.
DNMT1 mediates proliferation, migration and invasion of extravillous trophoblasts by regulating the methylation level of APLNR.
Title: DNMT1 mediates proliferation, migration and invasion of extravillous trophoblasts by regulating the methylation level of APLNR.
Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.
Title: Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.
Regulatory role of apelin receptor signaling in migration and differentiation of mouse embryonic stem cell-derived mesoderm cells and mesenchymal stem/stromal cells.
Title: Regulatory role of apelin receptor signaling in migration and differentiation of mouse embryonic stem cell-derived mesoderm cells and mesenchymal stem/stromal cells.
Cancer apelin receptor suppresses vascular mimicry in malignant melanoma.
Title: Cancer apelin receptor suppresses vascular mimicry in malignant melanoma.
The investigation of apelin and apelin receptor expressions in mouse endometrium during peri-implantation period.
Title: The investigation of apelin and apelin receptor expressions in mouse endometrium during peri-implantation period.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (8) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234444

UniSTS:234445 (e-PCR)
- UniSTS:234445

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables apelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adult heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apelin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrioventricular valve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
involved_in coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G protein-coupled receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of body fluid levels	IEA Inferred from Electronic Annotation more info
involved_in regulation of body fluid levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gap junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: apelin receptor

Names: G-protein coupled receptor APJ; MSR; angiotensin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.