Zfp260 zinc finger protein 260 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp260provided by MGI
Official Full Name: zinc finger protein 260provided by MGI
Primary source: MGI:MGI:1347071
See related: Ensembl:ENSMUSG00000049421 AllianceGenome:MGI:1347071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PEX1; Ozrf1; Zfp63; Znf260
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut epithelium; and heart. Orthologous to human ZNF260 (zinc finger protein 260). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 14.5), limb E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.26 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29794207..29807047)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30094782..30107622)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pex1 is a novel nuclear effector of ET-1 signaling and may be a regulator of the early stages of cardiac hypertrophy
Title: ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 260

Names: zfp-260

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011981.4 → NP_036111.2 zinc finger protein 260

Status: VALIDATED

Source sequence(s)

BC085180

Consensus CDS

CCDS21078.1

UniProtKB/Swiss-Prot

Q3U170, Q62513, Q8C2Q6, Q9R2B4

Related

ENSMUSP00000052200.6, ENSMUST00000050735.12

Conserved Domains (2) summary

COG5048
Location:22 → 401

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

29794207..29807047

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250583.1 → XP_011248885.1 zinc finger protein 260 isoform X1

UniProtKB/Swiss-Prot

Q3U170, Q62513, Q8C2Q6, Q9R2B4

Conserved Domains (2) summary

COG5048
Location:22 → 401

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011250584.4 → XP_011248886.1 zinc finger protein 260 isoform X1

UniProtKB/Swiss-Prot

Q3U170, Q62513, Q8C2Q6, Q9R2B4

Conserved Domains (2) summary

COG5048
Location:22 → 401

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]