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    Akr1c20 aldo-keto reductase family 1, member C20 [ Mus musculus (house mouse) ]

    Gene ID: 116852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1c20provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member C20provided by MGI
    Primary source
    MGI:MGI:2151104
    See related
    Ensembl:ENSMUSG00000054757 AllianceGenome:MGI:2151104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610528B18Rik
    Summary
    Predicted to enable several functions, including geranylgeranyl reductase activity; oxidoreductase activity, acting on CH-OH group of donors; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including doxorubicin metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 7.9), liver E18 (RPKM 4.0) and 1 other tissue See more
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    Genomic context

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    See Akr1c20 in Genome Data Viewer
    Location:
    13 A1; 13 2.51 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4536855..4573353, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4486856..4523354, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9973 Neighboring gene STARR-seq mESC enhancer starr_33508 Neighboring gene aldo-keto reductase family 1, member C6 Neighboring gene STARR-seq mESC enhancer starr_33510 Neighboring gene STARR-seq mESC enhancer starr_33513 Neighboring gene STARR-seq mESC enhancer starr_33514 Neighboring gene predicted gene, 40657 Neighboring gene aldo-keto reductase family 1, member C21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family. Matsumoto K, et al. Biol Pharm Bull, 2006 Mar. PMID 16508162
    2. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Vergnes L, et al. J Lipid Res, 2003 Mar. PMID 12562828
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Delta4-3-oxosteroid 5beta-reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldo-keto reductase (NADPH) activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables aldo-keto reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase (B-specific) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chlordecone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables geranylgeranyl reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketosteroid monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1, member C20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311132.1 → NP_001298061.1  aldo-keto reductase family 1, member C20

      See identical proteins and their annotated locations for NP_001298061.1

      Status: VALIDATED

      Source sequence(s)
      AC166056, AI661346, AK012162
      Consensus CDS
      CCDS79161.1
      UniProtKB/TrEMBL
      A0A1Y7VMC8, Q8VC77
      Related
      ENSMUSP00000079232.6, ENSMUST00000080361.13
      Conserved Domains (2) summary
      COG0656
      Location:5 → 317
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      4536855..4573353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247130.1 → XP_030102990.1  aldo-keto reductase family 1, member C20 isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VMC8
      Conserved Domains (1) summary
      cl00470
      Location:6 → 259
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    2. XM_006516466.1 → XP_006516529.1  aldo-keto reductase family 1, member C20 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VMC8
      Related
      ENSMUSP00000152648.2, ENSMUST00000221564.2
      Conserved Domains (1) summary
      cd19108
      Location:6 → 279
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    3. XM_006516465.1 → XP_006516528.1  aldo-keto reductase family 1, member C20 isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VMC8
      Conserved Domains (1) summary
      cd19108
      Location:6 → 286
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_054080.1: Suppressed sequence

      Description
      NM_054080.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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