Dapp1 dual adaptor for phosphotyrosine and 3-phosphoinositides 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dapp1provided by MGI
Official Full Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1provided by MGI
Primary source: MGI:MGI:1347063
See related: Ensembl:ENSMUSG00000028159 AllianceGenome:MGI:1347063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bam32
Summary: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.5), liver E14 (RPKM 5.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 63.98 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (137636768..137687331, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (137931007..137981549, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment.
Title: Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment.
Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in WKYMVm-Induced Microvascular Hyperpermeability.
Title: Bam32/DAPP1-Dependent Neutrophil Reactive Oxygen Species in WKYMVm-Induced Microvascular Hyperpermeability.
Results functionally demonstrated that Dapp1 modulates lung resistance in response to diesel exhaust particles exposure, thus providing evidence for a novel gene-environment interaction that influences asthma-related traits in mice.
Title: A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity.
These data show that Bam32 is important for optimal anti-trypanosome IgG antibody response and suppression of disease-promoting proinflammatory cytokines.
Title: The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.
our results identify Bam32 as a novel regulator of mast cell activation
Title: The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release.
Bam32 serves to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for Ag presentation function.
Title: Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells.
Bam32 is not required for germinal center (GC) initiation, but rather functions in a late checkpoint of GC progression associated with T cell recruitment and GC B cell survival.
Title: The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression.
Data show that Erk activation was diminished in LAT knock-in Bam32 knockout CD4(+) T cells.
Title: Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
The interaction of Bam32 with Lyn leads to Bam32 phosphorylation, which might play an important role in activating downstream signaling molecules.
Title: [Identification of proteins interacting with adaptor protein Bam32].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Names: B-cell adapter molecule of 32 kDa; b lymphocyte adapter protein Bam32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310753.1 → NP_001297682.1 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 2

See identical proteins and their annotated locations for NP_001297682.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC146607, AK169584, BF714724

Consensus CDS

CCDS80029.1

UniProtKB/TrEMBL

Q3TEK6, Q3UL29

Related

ENSMUSP00000119634.2, ENSMUST00000136613.4

Conserved Domains (3) summary

cd10573
Location:122 → 217

PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain

pfam00169
Location:125 → 214

PH; PH domain

cl15255
Location:14 → 78

SH2; Src homology 2 (SH2) domain
NM_011932.3 → NP_036062.1 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1

See identical proteins and their annotated locations for NP_036062.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC146607, AK145745, AK169584, BF714724

Consensus CDS

CCDS17864.1

UniProtKB/Swiss-Prot

Q9QXT1, Q9R178

UniProtKB/TrEMBL

Q3UK44, Q3UL29

Related

ENSMUSP00000029806.7, ENSMUST00000029806.13

Conserved Domains (3) summary

cd10355
Location:28 → 119

SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins

cd10573
Location:163 → 258

PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain

pfam00169
Location:166 → 255

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

137636768..137687331 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163110.1 → XP_036019003.1 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1

UniProtKB/TrEMBL

Q3UL29

Conserved Domains (2) summary

cd10355
Location:28 → 119

SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins

cl17171
Location:163 → 237

PH-like; Pleckstrin homology-like domain
XM_017319585.3 → XP_017175074.1 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

Conserved Domains (1) summary

cd10573
Location:41 → 136

PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain