Asb17 ankyrin repeat and SOCS box-containing 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asb17provided by MGI
Official Full Name: ankyrin repeat and SOCS box-containing 17provided by MGI
Primary source: MGI:MGI:1914022
See related: Ensembl:ENSMUSG00000038997 AllianceGenome:MGI:1914022
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933436O18Rik
Summary: Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB17 (ankyrin repeat and SOCS box containing 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 80.7) See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 78.68 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (153549884..153559252)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (153844247..153853615)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expressed from the third week post birth to adult; expressed in spermatogenic cells in adult mouse, but not in Leydig cells and epididymis
Title: Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.
expressed from the fourth week after birth to adult, with the highest expression in round spermatids
Title: Murine Asb-17 expression during mouse testis development and spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 17

Names: ASB-17; ankyrin repeat and SOCS box-containing protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025758.4 → NP_080034.2 ankyrin repeat and SOCS box protein 17

See identical proteins and their annotated locations for NP_080034.2

Status: PROVISIONAL

Source sequence(s)

AC087184

Consensus CDS

CCDS17922.1

UniProtKB/Swiss-Prot

Q8VHP9, Q9CUF9

Related

ENSMUSP00000041293.4, ENSMUST00000044089.4

Conserved Domains (3) summary

cd03716
Location:251 → 294

SOCS_ASB_like; SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable ...

pfam12796
Location:103 → 171

Ank_2; Ankyrin repeats (3 copies)

cl02529
Location:95 → 216

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...