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    Ren2 renin 2 tandem duplication of Ren1 [ Mus musculus (house mouse) ]

    Gene ID: 19702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ren2provided by MGI
    Official Full Name
    renin 2 tandem duplication of Ren1provided by MGI
    Primary source
    MGI:MGI:97899
    See related
    AllianceGenome:MGI:97899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ren; Rnr; Rn-2; Ren-2; Ren-B
    Summary
    Enables endopeptidase activity. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within positive regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including adrenal medulla; embryo mesenchyme; medulla oblongata alar plate mantle layer; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
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    Genomic context

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    See Ren2 in Genome Data Viewer
    Location:
    1 E4; 1
    Annotation release Status Assembly Chr Location
    108.20200622 latest, but not current GRCm38.p6 (GCF_000001635.26) 1 Unlocalized Scaffold (129S6/SvEvTac) NT_039192.2 (159748..169505, complement)

    Bibliography

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    Related articles in PubMed

    1. Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats. Vanecková I, et al. Kidney Blood Press Res, 2005. PMID 15795515
    2. Amino acid sequence of mouse submaxillary gland renin. Misono KS, et al. Proc Natl Acad Sci U S A, 1982 Aug. PMID 6812055, Free PMC Article
    3. Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor. Panthier JJ, et al. Nature, 1982 Jul 1. PMID 6283373
    4. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. Wei Y, et al. J Hepatol, 2008 Sep. PMID 18486983, Free PMC Article
    5. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat. Yamaleyeva LM, et al. Am J Physiol Heart Circ Physiol, 2007 Oct. PMID 17630347

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
      Title: Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
    2. Sex differences in blood pressure of aged Ren-2 transgenic rats.
      Title: Sex differences in blood pressure of aged Ren-2 transgenic rats.
    3. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
      Title: Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
    4. Suppression of ACE-ANG II axis in the circulation and kidney tissue, combined with augmentation of the intrarenal vasodilator ACE2-ANG 1-7 axis, is the main mechanism responsible for blood pressure-lowering effects of chronic hypoxia in mRen2 rat.
      Title: Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
    5. BP-lowering effect of sEH inhibition in I3C-induced Cyp1a1-Ren-2 transgenic rats.
      Title: Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
    6. Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
      Title: Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
    7. A deficitcin Ang-(1-7) in the brain of hypertensive (mRen2)27 rats maycbe a contributing factor to higher blood pressure and alteredcautonomic balance in this strain.
      Title: In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats.
    8. Data show that the GPR30 agonist G-1 mitigates the adverse effects of oestrogen loss on LV remodelling and the development of diastolic dysfunction in oophorectomized mRen2 Lew rats.
      Title: Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats.
    9. Renin and PPAR-gamma differentially contribute to the control of the length of cardiomyocytes.
      Title: Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}.
    10. Epoxide hydrolase inhibitors displays antihypertensive effects in Ren-2 transgenic rats with inducible malignant hypertension via an improvement of renal function.
      Title: Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiotensin maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiotensin maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_negative_effect gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cGMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    renin-2
    Names
    angiotensinogenase
    submandibular gland renin
    NP_112470.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031193.2 → NP_112470.2  renin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC011157, BG867251, BG869802
      UniProtKB/Swiss-Prot
      P00796, P70229, P97955, Q62155
      Conserved Domains (3) summary
      cd05487
      Location:98 → 423
      renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
      pfam00026
      Location:105 → 423
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:51 → 76
      A1_Propeptide; A1 Propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00796.1 GenPept UniProtKB/Swiss-Prot:P00796

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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