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    Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 13478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dpagt1provided by MGI
    Official Full Name
    dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by MGI
    Primary source
    MGI:MGI:1196396
    See related
    Ensembl:ENSMUSG00000032123 AllianceGenome:MGI:1196396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GPT; G1PT; Gnpta; Dpagt2
    Summary
    Enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; dolichol metabolic process; and dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 30.3), ovary adult (RPKM 28.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpagt1 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44237314..44247374)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44325857..44333895)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene histone H4 transcription factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058 Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene STARR-seq mESC enhancer starr_23963 Neighboring gene H2A.X variant histone Neighboring gene STARR-positive B cell enhancer ABC_E710 Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11, CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer ABC_E6726

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DPAGT1-Mediated Protein N-Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice. Li H, et al. Adv Sci (Weinh), 2020 Jul. PMID 32714760, Free PMC Article
    2. A Dpagt1 Missense Variant Causes Degenerative Retinopathy without Myasthenic Syndrome in Mice. Hyde LF, et al. Int J Mol Sci, 2022 Oct 9. PMID 36233305, Free PMC Article
    3. Structure and organization of mouse GlcNAc-1-phosphate transferase gene. Rajput B, et al. J Biol Chem, 1994 Apr 1. PMID 8043075
    4. Induction of dolichyl-saccharide intermediate biosynthesis corresponds to increased long chain cis-isoprenyltransferase activity during the mitogenic response in mouse B cells. Crick DC, et al. J Biol Chem, 1994 Apr 8. PMID 8144643
    5. Negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland. Ma J, et al. J Biol Chem, 1996 May 10. PMID 8626667

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
    Names
    N-acetylglucosamine-1-phosphate transferase
    UDP-N-acetylglucosamine lysosomal enzyme N-acetylglucosamine phosphotransferase
    dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
    dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 2
    NP_001351393.1
    NP_031901.2
    XP_006510054.1
    XP_006510055.1
    XP_006510058.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364464.1 → NP_001351393.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK008246, BM211613, BM899494, CN665943
      UniProtKB/TrEMBL
      Q9CPT1
      Conserved Domains (1) summary
      cd06855
      Location:1 → 210
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    2. NM_007875.3 → NP_031901.2  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 1

      See identical proteins and their annotated locations for NP_031901.2

      Status: VALIDATED

      Source sequence(s)
      AC122428, AC124577
      Consensus CDS
      CCDS23104.1
      UniProtKB/Swiss-Prot
      P42867, Q921W5
      Related
      ENSMUSP00000056282.4, ENSMUST00000054708.5
      Conserved Domains (1) summary
      cd06855
      Location:31 → 319
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44237314..44247374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509991.2 → XP_006510054.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

      Conserved Domains (1) summary
      cd06855
      Location:3 → 286
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    2. XM_006509992.3 → XP_006510055.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

      Conserved Domains (1) summary
      cd06855
      Location:35 → 264
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    3. XM_006509995.3 → XP_006510058.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

      See identical proteins and their annotated locations for XP_006510058.1

      UniProtKB/TrEMBL
      Q9CPT1
      Conserved Domains (1) summary
      cd06855
      Location:1 → 210
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42867.2 GenPept UniProtKB/Swiss-Prot:P42867

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