Ugt1a6a UDP glucuronosyltransferase 1 family, polypeptide A6A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ugt1a6aprovided by MGI
Official Full Name: UDP glucuronosyltransferase 1 family, polypeptide A6Aprovided by MGI
Primary source: MGI:MGI:2137698
See related: Ensembl:ENSMUSG00000054545 AllianceGenome:MGI:2137698
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UDPGT; UGT1.6; Ugt1a6; Ugt1a7; UGT1-06; UDPGT 1-6
Summary: Enables alpha-glucuronidase activity and glucuronosyltransferase activity. Involved in L-ascorbic acid biosynthetic process. Acts upstream of or within glucuronate metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 228.4), liver adult (RPKM 161.8) and 13 other tissues See more
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Genomic context

Location:: 1 D; 1 44.52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (88062531..88147724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88134809..88220002)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study provides evidence that UGT1A6A, acting on the serotonin pathway, regulates glucose induced insulin secretion under both normal and pathological conditions.
Title: Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells.
the difference in expression levels between Ugt1a6a and Ugt1a6b in the hippocampus led us to speculate that Ugt1a6a is likely the predominant catalyst of serotonin glucuronidation in the mouse brain.
Title: Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-glucuronidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-glucuronidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 4-chlorobiphenyl metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular glucuronidation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucuronate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucuronate metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 1-6

Names: UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1A6; phenol UDP-glucuronosyltransferase

NP_659545.2

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145079.3 → NP_659545.2 UDP-glucuronosyltransferase 1-6 precursor

See identical proteins and their annotated locations for NP_659545.2

Status: VALIDATED

Source sequence(s)

AC087780, AC087801

Consensus CDS

CCDS48314.1

UniProtKB/Swiss-Prot

P70692, Q62580, Q64435, Q6XL47

UniProtKB/TrEMBL

Q6NSR5

Related

ENSMUSP00000108759.2, ENSMUST00000113134.8

Conserved Domains (2) summary

PHA03392
Location:15 → 503

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:27 → 522

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase