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    Thbs2 thrombospondin 2 [ Mus musculus (house mouse) ]

    Gene ID: 21826, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Thbs2provided by MGI
    Official Full Name
    thrombospondin 2provided by MGI
    Primary source
    MGI:MGI:98738
    See related
    Ensembl:ENSMUSG00000023885 AllianceGenome:MGI:98738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSP2; Thbs-2
    Summary
    Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis. Located in basement membrane. Is expressed in several structures, including central nervous system; genitourinary system; jaw; mesothelium; and respiratory system. Orthologous to human THBS2 (thrombospondin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 44.4), limb E14.5 (RPKM 28.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thbs2 in Genome Data Viewer
    Location:
    17 A2; 17 8.95 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (14885762..14914524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (14665500..14694262, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38551 Neighboring gene VISTA enhancer mm1999 Neighboring gene predicted gene, 34916 Neighboring gene STARR-seq mESC enhancer starr_41894 Neighboring gene predicted gene, 53989 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 23352 Neighboring gene WD repeat domain 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thrombospondin-2 facilitates assembly of a type-I collagen-rich matrix in marrow stromal cells undergoing osteoblastic differentiation. Alford AI, et al. Connect Tissue Res, 2013. PMID 23763373, Free PMC Article
    2. Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice. Hankenson KD, et al. Matrix Biol, 2005 Aug. PMID 15979292
    3. Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype. Manley E Jr, et al. J Appl Physiol (1985), 2015 Oct 15. PMID 26272319, Free PMC Article
    4. Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice. Agah A, et al. Am J Pathol, 2005 Jul. PMID 15972954, Free PMC Article
    5. Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Krady MM, et al. Am J Pathol, 2008 Sep. PMID 18688033, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.
      Title: Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.
    2. Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice.
      Title: Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice.
    3. Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
      Title: Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
    4. Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
      Title: Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
    5. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
      Title: Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
    6. Thrombospondin-2 spatiotemporal expression in skeletal fractures.
      Title: Thrombospondin-2 spatiotemporal expression in skeletal fractures.
    7. Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
      Title: Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
    8. TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
      Title: TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
    9. Findings demonstrate a novel link between TSP2, LOX, and miR-29 that is regulated by the presence or absence of TSP2 in the extracellular environment, forming a feedback loop between cells and its extracellular matrix substrate.
      Title: Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.
    10. Though the TSP2-deficient mice developed obesity and hyperglycemia comparable with diabetic control mice, they exhibited significantly improved healing, characterized by accelerated reepithelialization and increased granulation tissue formation, fibroblast migration, and blood vessel maturation.
      Title: Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in platelet alpha granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thrombospondin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011581.3 → NP_035711.2  thrombospondin-2 precursor

      See identical proteins and their annotated locations for NP_035711.2

      Status: VALIDATED

      Source sequence(s)
      AK132508, AK142552, AK165881, CJ049934
      Consensus CDS
      CCDS49958.1
      UniProtKB/Swiss-Prot
      Q03350, Q8CG21
      UniProtKB/TrEMBL
      Q7TMT3
      Related
      ENSMUSP00000128308.2, ENSMUST00000170872.3
      Conserved Domains (10) summary
      smart00209
      Location:497 → 549
      TSP1; Thrombospondin type 1 repeats
      smart00210
      Location:21 → 213
      TSPN; Thrombospondin N-terminal -like domains
      sd00001
      Location:847 → 884
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:789 → 823
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:693 → 728
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:385 → 430
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:320 → 374
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:848 → 884
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:974 → 1171
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:652 → 691
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      14885762..14914524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03350.2 GenPept UniProtKB/Swiss-Prot:Q03350

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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