Bcl9l B cell CLL/lymphoma 9-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl9lprovided by MGI
Official Full Name: B cell CLL/lymphoma 9-likeprovided by MGI
Primary source: MGI:MGI:1933114
See related: Ensembl:ENSMUSG00000063382 AllianceGenome:MGI:1933114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B9L; BCL9-2; DLNB11
Summary: Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including respiratory system cartilage; sensory organ; skeleton; trunk unsegmented mesenchyme; and vibrissa. Orthologous to human BCL9L (BCL9 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 17.6), lung adult (RPKM 16.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44394103..44423203)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44482738..44511906)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.
Title: Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.
BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
Title: BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
BCL9-2 induces ER positive breast cancers in vivo, regulates ER expression by a novel ss-catenin independent mechanism in breast cancer cells.
Title: The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked.
Title: Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
BCL9-2 promotes early phases of intestinal tumor progression in humans and in transgenic mice. BCL9-2 increases the expression of a subset of canonical Wnt target genes but also regulates genes that are required for early stages of tumor progression.
Title: BCL9-2 promotes early stages of intestinal tumor progression.
We demonstrated that nuclear B9L expression was closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers.
Title: Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bcl9l (e-PCR), detects polymorphism
- UniSTS:498745

NoName (e-PCR)
- UniSTS:236116

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin-TCF complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell CLL/lymphoma 9-like protein

Names: B-cell lymphoma 9-like protein; BCL9-like protein; BCL9-related beta-catenin-binding protein; nuclear co-factor of beta-catenin signalling; protein BCL9-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357490.2 → NP_001344419.1 B-cell CLL/lymphoma 9-like protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC122428, AC125129

Consensus CDS

CCDS90549.1

Related

ENSMUSP00000151342.2, ENSMUST00000220303.2

Conserved Domains (2) summary

PHA03247
Location:832 → 1314

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:358 → 392

BCL9; B-cell lymphoma 9 protein
NM_001421307.1 → NP_001408236.1 B-cell CLL/lymphoma 9-like protein isoform 1

Status: VALIDATED

Source sequence(s)

AC122428, AC125129

UniProtKB/Swiss-Prot

Q641L9, Q67FY2, Q6GQY0, Q6I7B5
NM_030256.4 → NP_084532.2 B-cell CLL/lymphoma 9-like protein isoform 1

See identical proteins and their annotated locations for NP_084532.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC125129

Consensus CDS

CCDS40601.1

UniProtKB/Swiss-Prot

Q641L9, Q67FY2, Q6GQY0, Q6I7B5

Related

ENSMUSP00000074516.6, ENSMUST00000074989.7

Conserved Domains (2) summary

PHA03247
Location:869 → 1351

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:395 → 429

BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44394103..44423203

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244728.1 → XP_030100588.1 B-cell CLL/lymphoma 9-like protein isoform X2

Conserved Domains (2) summary

PHA03247
Location:832 → 1314

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:358 → 392

BCL9; B-cell lymphoma 9 protein
XM_006510703.4 → XP_006510766.1 B-cell CLL/lymphoma 9-like protein isoform X1

See identical proteins and their annotated locations for XP_006510766.1

UniProtKB/Swiss-Prot

Q641L9, Q67FY2, Q6GQY0, Q6I7B5

Conserved Domains (2) summary

PHA03247
Location:869 → 1351

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:395 → 429

BCL9; B-cell lymphoma 9 protein
XM_006510702.5 → XP_006510765.1 B-cell CLL/lymphoma 9-like protein isoform X1

See identical proteins and their annotated locations for XP_006510765.1

UniProtKB/Swiss-Prot

Q641L9, Q67FY2, Q6GQY0, Q6I7B5

Related

ENSMUSP00000151837.2, ENSMUST00000218183.2

Conserved Domains (2) summary

PHA03247
Location:869 → 1351

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:395 → 429

BCL9; B-cell lymphoma 9 protein
XM_036155412.1 → XP_036011305.1 B-cell CLL/lymphoma 9-like protein isoform X2

Conserved Domains (2) summary

PHA03247
Location:832 → 1314

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:358 → 392

BCL9; B-cell lymphoma 9 protein
XM_006510704.4 → XP_006510767.1 B-cell CLL/lymphoma 9-like protein isoform X1

See identical proteins and their annotated locations for XP_006510767.1

UniProtKB/Swiss-Prot

Q641L9, Q67FY2, Q6GQY0, Q6I7B5

Conserved Domains (2) summary

PHA03247
Location:869 → 1351

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:395 → 429

BCL9; B-cell lymphoma 9 protein