Gp2 glycoprotein 2 zymogen granule membrane [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gp2provided by MGI
Official Full Name: glycoprotein 2 zymogen granule membraneprovided by MGI
Primary source: MGI:MGI:1914383
See related: Ensembl:ENSMUSG00000030954 AllianceGenome:MGI:1914383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310037I18Rik
Summary: Enables antigen binding activity. Acts upstream of or within antigen transcytosis by M cells in mucosal-associated lymphoid tissue and establishment of localization in cell. Located in apical plasma membrane and endosome. Is expressed in trachea epithelium. Orthologous to human GP2 (glycoprotein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 60.9), spleen adult (RPKM 41.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 63.88 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119041760..119058495, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (119442537..119459272, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation.
Title: Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation.
Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.
Title: Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.
GP2 is a popular secretory product released from mucous glands and secretory cells and may support defense mechanisms against pathogenic bacteria in the tubular organs open to the external milieu.
Title: The broad distribution of GP2 in mucous glands and secretory products.
GP2-expressing cells in paranasal sinuses are in the lineage of goblet cells.
Title: A novel type of cells expressing GP2 in the respiratory epithelium of the paranasal sinuses in mice.
glycoprotein 2 (GP2), specifically expressed on the apical plasma membrane of M cells among enterocytes, serves as a transcytotic receptor for mucosal antigens
Title: Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Tightly linked to homologue THP. A Gp2 knockout mouse was established which does express THP.
Title: GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome.
unlikely that GP2 serves a major intracellular role within the acinar cell, may be active after it is secreted
Title: Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

03.MHAa96a3.seq (e-PCR)
- UniSTS:122726

NoName (e-PCR)
- UniSTS:487573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables antigen binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen transcytosis by M cells in mucosal-associated lymphoid tissue	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen transcytosis by M cells in mucosal-associated lymphoid tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in neutrophil migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pancreatic secretory granule membrane major glycoprotein GP2

Names: pancreatic zymogen granule membrane protein GP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025989.4 → NP_080265.3 pancreatic secretory granule membrane major glycoprotein GP2 precursor

Status: VALIDATED

Source sequence(s)

AC125147

Consensus CDS

CCDS21779.1

UniProtKB/Swiss-Prot

Q9D733

UniProtKB/TrEMBL

A0A0R4J0B9

Related

ENSMUSP00000033255.7, ENSMUST00000033255.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

119041760..119058495 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508121.2 → XP_006508184.1 pancreatic secretory granule membrane major glycoprotein GP2 isoform X1

UniProtKB/TrEMBL

A0A0R4J0B9

Conserved Domains (1) summary

pfam00100
Location:243 → 492

Zona_pellucida; Zona pellucida-like domain