Ptprz1 protein tyrosine phosphatase receptor type Z, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprz1provided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Z, polypeptide 1provided by MGI
Primary source: MGI:MGI:97816
See related: Ensembl:ENSMUSG00000068748 AllianceGenome:MGI:97816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptpz; Ptprz; RPTPz; PTPbeta; PTPzeta; DSD-1-PG; Rptpbeta; R-PTP-zeta
Summary: Enables protein tyrosine phosphatase activity. Involved in several processes, including oligodendrocyte differentiation; peptidyl-tyrosine dephosphorylation; and regulation of myelination. Acts upstream of or within axonogenesis and hematopoietic progenitor cell differentiation. Located in perineuronal net and plasma membrane. Is active in synapse. Is expressed in several structures, including central nervous system; cranial nerve; eye; genitourinary system; and limb. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 46.4), whole brain E14.5 (RPKM 27.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 9.92 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (22875302..23052915)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (22875315..23052916)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
Title: Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.
Title: Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.
Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
Title: Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
Title: IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
Title: Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
Protein tyrosine phosphatase receptor-zeta1 deletion triggers defective heart morphogenesis in mice and zebrafish.
Title: Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish.
The protein tyrosine phosphatase RPTPzeta/phosphacan is critical for perineuronal net structure.
Title: The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure.
Ptprz knock-out mice exhibited an increased locomotor response to novelty, whereas their locomotor response to methamphetamine (METH) was reduced. Furthermore, Ptprz deficiency may reduce cell surface dopamine (DA) transporter proteins expression, thereby reducing METH-evoked DA release.
Title: Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.
results suggest that the extracellular region of PTPRZ, including the secretory isoform, is crucial for behavioral responses to novelty and the formation of aversive memories, whereas the PTPase activities of PTPRZ receptor isoforms are involved in regulating the dopaminergic system
Title: Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ).
High PTPRZ1 expression is associated with glioblastoma.
Title: Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498441 (e-PCR)
- UniSTS:498441

Ptprz1 (e-PCR), detects polymorphism
- UniSTS:498441

Ptprz1 (e-PCR), detects polymorphism
- UniSTS:498442

fk94b09.x1 (e-PCR)
- UniSTS:201755

PMC84149P1 (e-PCR)
- UniSTS:273440

PMC343947P1 (e-PCR)
- UniSTS:273199

AI850339 (e-PCR)
- UniSTS:185657

NoName (e-PCR)
- UniSTS:225108

D11S3076 (e-PCR)
- UniSTS:152173

PMC164283P1 (e-PCR)
- UniSTS:271481

Ptprz1 (e-PCR), detects polymorphism
- UniSTS:498354

G44369 (e-PCR)
- UniSTS:95155

fk89b04.x1 (e-PCR)
- UniSTS:201675

D11S3553 (e-PCR)
- UniSTS:152792

fe50c07.y1 (e-PCR)
- UniSTS:196579

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonal fasciculation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Schwann cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oligodendrocyte progenitor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perineuronal net	IDA Inferred from Direct Assay more info	PubMed
located_in perineuronal net	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase zeta

Names: 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; phosphacan

NP_001074775.1

EC 3.1.3.48

NP_001297993.1

EC 3.1.3.48

NP_001348278.1

EC 3.1.3.48

NP_001389981.1

EC 3.1.3.48

NP_001389982.1

EC 3.1.3.48

NP_001389983.1

EC 3.1.3.48

NP_035349.2

EC 3.1.3.48

XP_006505075.1

EC 3.1.3.48

XP_006505076.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081306.2 → NP_001074775.1 receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor

See identical proteins and their annotated locations for NP_001074775.1

Status: VALIDATED

Source sequence(s)

AC133599, AC134445

Consensus CDS

CCDS39437.1

UniProtKB/Swiss-Prot

B9EKR1

Related

ENSMUSP00000088056.4, ENSMUST00000090568.7

Conserved Domains (4) summary

smart00194
Location:1713 → 1988

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1749 → 1988

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
NM_001311064.2 → NP_001297993.1 receptor-type tyrosine-protein phosphatase zeta isoform 4 precursor

See identical proteins and their annotated locations for NP_001297993.1

Status: VALIDATED

Source sequence(s)

AC133599, AC134445

Consensus CDS

CCDS80493.1

UniProtKB/TrEMBL

B2RXS8

Related

ENSMUSP00000143902.2, ENSMUST00000202102.2

Conserved Domains (4) summary

smart00194
Location:864 → 1139

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:900 → 1139

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
NM_001361349.2 → NP_001348278.1 receptor-type tyrosine-protein phosphatase zeta isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC133599, AC134445

Conserved Domains (4) summary

smart00194
Location:864 → 1132

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1191 → 1421

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain
NM_001403052.1 → NP_001389981.1 receptor-type tyrosine-protein phosphatase zeta isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC133599, AC134445
NM_001403053.1 → NP_001389982.1 receptor-type tyrosine-protein phosphatase zeta isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AC133599, AC134445
NM_001403054.1 → NP_001389983.1 receptor-type tyrosine-protein phosphatase zeta isoform 8 precursor

Status: VALIDATED

Source sequence(s)

AC133599, AC134445
NM_011219.3 → NP_035349.2 receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC133599, AC134445

Consensus CDS

CCDS90032.1

UniProtKB/TrEMBL

A0A0J9YVD2, A0AAU7E9J5, A0AAU7E9T4

Related

ENSMUSP00000144605.2, ENSMUST00000202579.4

Conserved Domains (2) summary

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

pfam00041
Location:313 → 401

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

22875302..23052915

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505012.3 → XP_006505075.1 receptor-type tyrosine-protein phosphatase zeta isoform X1

Conserved Domains (4) summary

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

cd17669
Location:2080 → 2283

R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2

pfam00041
Location:313 → 395

fn3; Fibronectin type III domain

cl28904
Location:1714 → 1997

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006505013.3 → XP_006505076.1 receptor-type tyrosine-protein phosphatase zeta isoform X2

Conserved Domains (4) summary

cd03122
Location:45 → 298

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

cd17669
Location:2073 → 2276

R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2

pfam00041
Location:313 → 395

fn3; Fibronectin type III domain

cl28904
Location:1714 → 1990

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily