Nr5a2 nuclear receptor subfamily 5, group A, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr5a2provided by MGI
Official Full Name: nuclear receptor subfamily 5, group A, member 2provided by MGI
Primary source: MGI:MGI:1346834
See related: Ensembl:ENSMUSG00000026398 AllianceGenome:MGI:1346834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ftf; LRH-1; UF2-H3B; D1Ertd308e
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; cholesterol homeostasis; and pancreas morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; ear; early conceptus; and gonad. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 23.7), liver adult (RPKM 4.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 59.98 cM; 1 E4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (136770300..136888186, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (136842562..136960448, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nr5a2 is dispensable for zygotic genome activation but essential for morula development.
Title: Nr5a2 is dispensable for zygotic genome activation but essential for morula development.
Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2.
Title: Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2.
Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle.
Title: Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle.
Ovarian ERbeta cistrome and transcriptome reveal chromatin interaction with LRH-1.
Title: Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1.
Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
Title: Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis.
Title: LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis.
Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.
Title: Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.
NR5A2 as a potential target for exercise to improve metabolic syndrome.
Title: NR5A2 as a potential target for exercise to improve metabolic syndrome.
Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
Title: Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
Zygotic genome activation by the totipotency pioneer factor Nr5a2.
Title: Zygotic genome activation by the totipotency pioneer factor Nr5a2.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136280 (e-PCR)
- UniSTS:210273

RH126840 (e-PCR)
- UniSTS:167266

D1Ertd811e (e-PCR), detects polymorphism
- UniSTS:167297

Nr5a2 (e-PCR), detects polymorphism
- UniSTS:496779

Nr5a2 (e-PCR), detects polymorphism
- UniSTS:496780

Nr5a2 (e-PCR), detects polymorphism
- UniSTS:496781

PMC193920P1 (e-PCR)
- UniSTS:271761

Nr5a2 (e-PCR), detects polymorphism
- UniSTS:547280

25.MHAa58c1.seq (e-PCR)
- UniSTS:186334

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acinar cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bile acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcineurin-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor subfamily 5 group A member 2

Names: fetoprotein transcription factor; liver receptor homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159769.2 → NP_001153241.1 nuclear receptor subfamily 5 group A member 2 isoform 2

See identical proteins and their annotated locations for NP_001153241.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) contains a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC124814

Consensus CDS

CCDS48382.1

UniProtKB/TrEMBL

Q1WLP7

Related

ENSMUSP00000141495.2, ENSMUST00000192929.6

Conserved Domains (2) summary

cd07069
Location:259 → 499

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:46 → 138

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
NM_030676.3 → NP_109601.1 nuclear receptor subfamily 5 group A member 2 isoform 1

See identical proteins and their annotated locations for NP_109601.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC120182, AC124814, BC137845

Consensus CDS

CCDS15328.1

UniProtKB/Swiss-Prot

B9EHF9, P45448

Related

ENSMUSP00000027649.8, ENSMUST00000027649.14

Conserved Domains (2) summary

cd07069
Location:320 → 560

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:107 → 199

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

136770300..136888186 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529621.3 → XP_006529684.1 nuclear receptor subfamily 5 group A member 2 isoform X1

UniProtKB/TrEMBL

A0A0A6YY04

Related

ENSMUSP00000142219.2, ENSMUST00000192357.6

Conserved Domains (2) summary

cd07069
Location:299 → 539

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:86 → 178

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
XM_006529622.4 → XP_006529685.1 nuclear receptor subfamily 5 group A member 2 isoform X2

See identical proteins and their annotated locations for XP_006529685.1

UniProtKB/TrEMBL

Q1WLP7

Related

ENSMUSP00000129071.2, ENSMUST00000168126.7

Conserved Domains (2) summary

cd07069
Location:259 → 499

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:46 → 138

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers