Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmtm5provided by MGI
Official Full Name: CKLF-like MARVEL transmembrane domain containing 5provided by MGI
Primary source: MGI:MGI:2447164
See related: Ensembl:ENSMUSG00000040759 AllianceGenome:MGI:2447164
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cklfsf5; 1500005P16Rik; 2900052H21Rik
Summary: Predicted to enable cytokine activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be located in extracellular space. Predicted to be active in membrane. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and skeleton. Orthologous to human CMTM5 (CKLF like MARVEL transmembrane domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 55.6), cerebellum adult (RPKM 11.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.0 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55173927..55176734)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54936176..54943045)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the Novel Myelin Protein CMTM5 in Multiple Sclerosis Lesions and Its Involvement in Oligodendroglial Stress Responses.
Title: Loss of the Novel Myelin Protein CMTM5 in Multiple Sclerosis Lesions and Its Involvement in Oligodendroglial Stress Responses.
Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5.
Title: Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 5

Names: chemokine-like factor super family 5; chemokine-like factor superfamily 5; chemokine-like factor superfamily member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026066.2 → NP_080342.1 CKLF-like MARVEL transmembrane domain-containing protein 5 isoform 2

See identical proteins and their annotated locations for NP_080342.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK013666

Consensus CDS

CCDS27105.1

UniProtKB/Swiss-Prot

Q9D6G9, Q9DB66

Related

ENSMUSP00000036138.7, ENSMUST00000037814.8

Conserved Domains (1) summary

pfam01284
Location:29 → 139

MARVEL; Membrane-associating domain
NM_029390.1 → NP_083666.1 CKLF-like MARVEL transmembrane domain-containing protein 5 isoform 1

See identical proteins and their annotated locations for NP_083666.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

DQ115983

Consensus CDS

CCDS88667.1

UniProtKB/TrEMBL

Q45TP8

Related

ENSMUSP00000153874.2, ENSMUST00000227441.2