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    ftsh4 FTSH protease 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817154, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ftsh4
    Official Full Name
    FTSH protease 4
    Primary source
    TAIR:AT2G26140
    Locus tag
    AT2G26140
    See related
    Araport:AT2G26140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FTSH protease 4; T19L18.5; T19L18_5
    Summary
    encodes an FtsH protease that is localized to the mitochondrion
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    Genomic context

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    See ftsh4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (11131578..11135465, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING/U-box protein with C6HC-type zinc finger Neighboring gene RING/U-box protein with C6HC-type zinc finger Neighboring gene heat shock transcription factor A2 Neighboring gene F-box SKIP23-like protein (DUF295)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impairment of Meristem Proliferation in Plants Lacking the Mitochondrial Protease AtFTSH4. Dolzblasz A, et al. Int J Mol Sci, 2018 Mar 14. PMID 29538317, Free PMC Article
    2. Identification of Physiological Substrates and Binding Partners of the Plant Mitochondrial Protease FTSH4 by the Trapping Approach. Opalińska M, et al. Int J Mol Sci, 2017 Nov 18. PMID 29156584, Free PMC Article
    3. The Arabidopsis Mitochondrial Protease FtSH4 Is Involved in Leaf Senescence via Regulation of WRKY-Dependent Salicylic Acid Accumulation and Signaling. Zhang S, et al. Plant Physiol, 2017 Apr. PMID 28250067, Free PMC Article
    4. The mitochondrial protease AtFTSH4 safeguards Arabidopsis shoot apical meristem function. Dolzblasz A, et al. Sci Rep, 2016 Jun 20. PMID 27321362, Free PMC Article
    5. AtFtsH4 perturbs the mitochondrial respiratory chain complexes and auxin homeostasis in Arabidopsis. Zhang S, et al. Plant Signal Behav, 2014. PMID 25763704, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FTSH4 and OMA1 mitochondrial proteases reduce moderate heat stress-induced protein aggregation.
      Title: FTSH4 and OMA1 mitochondrial proteases reduce moderate heat stress-induced protein aggregation.
    2. the abundance of the Tim17-2 protein, an essential component of the TIM17:23 translocase (Tim17-2 together with Tim50 and Tim23), is directly controlled by the proteolytic activity of FTSH4.
      Title: The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component.
    3. Growth arrest in the ftsh4-1 mutant is caused by cell cycle dysregulation in addition to the loss of stem cell identity.
      Title: Impairment of Meristem Proliferation in Plants Lacking the Mitochondrial Protease AtFTSH4.
    4. Data revealed several putative targets of FTSH4, novel (mitochondrial pyruvate carrier 4 (MPC4) and Pam18-2) and known (Tim17-2) substrates of this protease. Furthermore, These results demonstrate that FTSH4 degrades damaged proteins by oxidative stress in mitochondria and provide new insights into the function of FTSH4 in the maintenance of plant mitochondrial proteome.
      Title: Identification of Physiological Substrates and Binding Partners of the Plant Mitochondrial Protease FTSH4 by the Trapping Approach.
    5. Maintaining mitochondria functionality within the The shoot apical meristem, dependent on AtFTSH4, is vital to preserving stem cell activity throughout development
      Title: The mitochondrial protease AtFTSH4 safeguards Arabidopsis shoot apical meristem function.
    6. Loss of function of transcription factor WRKY75 in the mitochondrial protease ftsh4-4 mutants decreased the levels of salicylic acid (SA) and reversed the senescence phenotype.
      Title: The Arabidopsis Mitochondrial Protease FtSH4 Is Involved in Leaf Senescence via Regulation of WRKY-Dependent Salicylic Acid Accumulation and Signaling.
    7. the loss of FtsH4 regulates development and architecture by mediating the peroxidase-dependent interplay between hydrogen peroxide and auxin homeostasis
      Title: AtFtsH4 perturbs the mitochondrial respiratory chain complexes and auxin homeostasis in Arabidopsis.
    8. mitochondrial FtSH4 gene-mediated peroxidase accumulation regulates arabidopsis architecture
      Title: Perturbation of auxin homeostasis caused by mitochondrial FtSH4 gene-mediated peroxidase accumulation regulates arabidopsis architecture.
    9. processing of AtFtsH4 precursor by mitochondrial processing peptidase
      Title: Two-step processing of AtFtsH4 precursor by mitochondrial processing peptidase in Arabidopsis thaliana.
    10. Lack of AtFtsH4 results in impairment of organelle development and Arabidopsis leaf morphology under short-day conditions.
      Title: The lack of mitochondrial AtFtsH4 protease alters Arabidopsis leaf morphology at the late stage of rosette development under short-day photoperiod.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    • At2g26140_Arabidopsis_lyrata_ssp._lyrata_CAN1 (e-PCR)
    • At2g26140_Arabidopsis_lyrata_ssp._petraea_GER1 (e-PCR)
    NM_128172.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within meristem maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    FTSH protease 4
    NP_565616.1
    • FTSH protease 4 (ftsh4); FUNCTIONS IN: metallopeptidase activity, ATP-dependent peptidase activity, ATPase activity; INVOLVED IN: proteolysis, protein catabolic process; LOCATED IN: mitochondrion, plastid, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M41, FtsH (InterPro:IPR005936), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peptidase M41 (InterPro:IPR000642), Peptidase S16, Lon protease, C-terminal (InterPro:IPR001984); BEST Arabidopsis thaliana protein match is: FTSH protease 11 (TAIR:AT5G53170.1); Has 39775 Blast hits to 37259 proteins in 3240 species: Archae - 1584; Bacteria - 15744; Metazoa - 5149; Fungi - 3764; Plants - 3335; Viruses - 40; Other Eukaryotes - 10159 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11131578..11135465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128172.4 → NP_565616.1  FTSH protease 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80983, Q56ZW8
      UniProtKB/TrEMBL
      A0A178VQU1, A0A654EWA1
      Conserved Domains (2) summary
      PRK09862
      Location:135 → 282
      PRK09862; ATP-dependent protease
      TIGR01241
      Location:221 → 655
      FtsH_fam; ATP-dependent metalloprotease FtsH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80983.2

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