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    TNO1 TGN-related, localized SYP41 interacting protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839062, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TNO1
    Official Full Name
    TGN-related, localized SYP41 interacting protein
    Primary source
    TAIR:AT1G24460
    Locus tag
    AT1G24460
    See related
    Araport:AT1G24460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F21J9.12; TGN-localized SYP41 interacting protein
    Summary
    Encodes a novel protein that co-immunoprecipitates with SYP41. It is involved in vacuolar trafficking and salt tolerance, potentially via a role in vesicle fusion and in maintaining TGN structure or identity. Mutants display delayed formation of the Brefeldin A (BFA) compartment in cotyledons upon application of BFA.
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    Genomic context

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    See TNO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (8665874..8672651)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Ribonuclease III family protein Neighboring gene beta-ketoacyl reductase 2 Neighboring gene uncharacterized protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of trans-Golgi network t-SNAREs rescues vacuolar trafficking and TGN morphology defects in a putative tethering factor mutant. Yang X, et al. Plant J, 2019 Aug. PMID 31009161
    2. TNO1, a TGN-localized SNARE-interacting protein, modulates root skewing in Arabidopsis thaliana. Roy R, et al. BMC Plant Biol, 2017 Apr 11. PMID 28399805, Free PMC Article
    3. TNO1 is involved in salt tolerance and vacuolar trafficking in Arabidopsis. Kim SJ, et al. Plant Physiol, 2011 Jun. PMID 21521696, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198156.2
    NM_102291.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within circumnutation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to lithium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mannitol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to potassium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in root epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in root morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle tethering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TGN-related, localized SYP41 interacting protein
    NP_001185085.1
    • unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT4G31570.1).
    NP_173855.5
    • unknown protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT4G31570.1); Has 181008 Blast hits to 85359 proteins in 3551 species: Archae - 3290; Bacteria - 48304; Metazoa - 70793; Fungi - 13943; Plants - 10118; Viruses - 785; Other Eukaryotes - 33775 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8665874..8672651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198156.2 → NP_001185085.1  TGN-related, localized SYP41 interacting protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F1BCU1, F4I9A2, Q8GXQ6, Q9FYL7
      Conserved Domains (2) summary
      COG1196
      Location:850 → 1602
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:324 → 1079
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_102291.5 → NP_173855.5  TGN-related, localized SYP41 interacting protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173855.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F1BCU1, F4I9A2, Q8GXQ6, Q9FYL7
      UniProtKB/TrEMBL
      F4I9A1
      Conserved Domains (2) summary
      COG1196
      Location:785 → 1443
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:324 → 1079
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version

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