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    CLPB4 casein lytic proteinase B4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817052, updated on 18-Sep-2024

    Summary

    Official Symbol
    CLPB4
    Official Full Name
    casein lytic proteinase B4
    Primary source
    TAIR:AT2G25140
    Locus tag
    AT2G25140
    See related
    Araport:AT2G25140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CASEIN LYTIC PROTEINASE B-M; casein lytic proteinase B4; CLPB-M; F13D4.100; F13D4_100; HEAT SHOCK PROTEIN 98.7; HSP98.7
    Summary
    Encodes ClpB4, which belongs to the Casein lytic proteinase/heat shock protein 100 (Clp/Hsp100) family. Targeted to the mitochondrion, also referred to as ClpB-m. Transcripts of ClpB4 accumulate dramatically at high temperatures, suggesting that it may be involved in response to heat stress.
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    Genomic context

    See CLPB4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (10697629..10702203, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ARM repeat superfamily protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene cytochrome P450, family 82, subfamily F, polypeptide 1

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_128071.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    casein lytic proteinase B4
    NP_565586.1
    • casein lytic proteinase B4 (CLPB4); FUNCTIONS IN: nucleoside-triphosphatase activity, ATPase activity, nucleotide binding, ATP binding; INVOLVED IN: response to heat; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA-type, core (InterPro:IPR003959), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpB (InterPro:IPR017730), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), Clp, N-terminal (InterPro:IPR004176); BEST Arabidopsis thaliana protein match is: casein lytic proteinase B3 (TAIR:AT5G15450.1); Has 30488 Blast hits to 27328 proteins in 3166 species: Archae - 421; Bacteria - 19864; Metazoa - 870; Fungi - 613; Plants - 740; Viruses - 7; Other Eukaryotes - 7973 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10697629..10702203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128071.3NP_565586.1  casein lytic proteinase B4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYJ7
      UniProtKB/TrEMBL
      A0A178VSB4, A0A654EXJ3
      Conserved Domains (5) summary
      cd00009
      Location:262422
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR03346
      Location:88949
      chaperone_ClpB; ATP-dependent chaperone ClpB
      pfam02861
      Location:99151
      Clp_N; Clp amino terminal domain, pathogenicity island component
      pfam07724
      Location:683850
      AAA_2; AAA domain (Cdc48 subfamily)
      pfam10431
      Location:857937
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein