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    ALDH10A8 aldehyde dehydrogenase 10A8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843831, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALDH10A8
    Official Full Name
    aldehyde dehydrogenase 10A8
    Primary source
    TAIR:AT1G74920
    Locus tag
    AT1G74920
    See related
    Araport:AT1G74920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aldehyde dehydrogenase 10A8; F25A4.11; F25A4_11
    Summary
    ALDH10A8 encodes a protein that has not been functionally characterized, but it is similar to an Arabidopsis protein that has betaine aldehyde dehydrogenase and aminoaldehyde dehydrogenase activity. ALDH10A8 localizes to leucoplasts. aldh10a8 mutant plants are more susceptible to NaCl and dehydration stress.
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    Genomic context

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    See ALDH10A8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (28138997..28142837, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ADP-glucose pyrophosphorylase family protein Neighboring gene uncharacterized protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene cyclin-dependent kinase, putative (DUF581)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for ALDH10 enzymes in γ-butyrobetaine synthesis, seed development, germination, and salt tolerance in Arabidopsis. Jacques F, et al. J Exp Bot, 2020 Dec 31. PMID 32845293
    2. Arabidopsis aldehyde dehydrogenase 10 family members confer salt tolerance through putrescine-derived 4-aminobutyrate (GABA) production. Zarei A, et al. Sci Rep, 2016 Oct 11. PMID 27725774, Free PMC Article
    3. Overexpression of ALDH10A8 and ALDH10A9 Genes Provides Insight into Their Role in Glycine Betaine Synthesis and Affects Primary Metabolism in Arabidopsis thaliana. Missihoun TD, et al. Plant Cell Physiol, 2015 Sep. PMID 26169197
    4. Betaine aldehyde dehydrogenase genes from Arabidopsis with different sub-cellular localization affect stress responses. Missihoun TD, et al. Planta, 2011 Feb. PMID 21053011
    5. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The pH optima for activity and catalytic efficiency of recombinant AtALDH10A8 with 3-aminopropanal as substrate was 10.5 and 8.5, respectively, whereas the optima for AtALDH10A9 were approximately 9.5.
      Title: Arabidopsis aldehyde dehydrogenase 10 family members confer salt tolerance through putrescine-derived 4-aminobutyrate (GABA) production.
    2. ALDH10A8 and ALDH10A9 are involved in the synthesis of glycine betaine in Arabidopsis.
      Title: Overexpression of ALDH10A8 and ALDH10A9 Genes Provides Insight into Their Role in Glycine Betaine Synthesis and Affects Primary Metabolism in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198470.1
    NM_106150.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminobutyraldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables betaine-aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-guanidinobutyraldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular detoxification of aldehyde IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine biosynthetic process from choline IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine biosynthetic process from choline IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in leucoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase 10A8
    NP_001185399.1
    • aldehyde dehydrogenase 10A8 (ALDH10A8); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, oxidoreductase activity; INVOLVED IN: oxidation reduction, metabolic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 10A9 (TAIR:AT3G48170.1).
    NP_565094.1
    • aldehyde dehydrogenase 10A8 (ALDH10A8); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, oxidoreductase activity; INVOLVED IN: oxidation reduction, glycine betaine biosynthetic process from choline, metabolic process; LOCATED IN: cell wall; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 10A9 (TAIR:AT3G48170.1); Has 62964 Blast hits to 62643 proteins in 3067 species: Archae - 487; Bacteria - 36441; Metazoa - 2628; Fungi - 2124; Plants - 2053; Viruses - 0; Other Eukaryotes - 19231 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28138997..28142837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106150.4 → NP_565094.1  aldehyde dehydrogenase 10A8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56ZQ8, Q9S795
      UniProtKB/TrEMBL
      A0A178W4Y2, A0A5S9WUG4
      Conserved Domains (1) summary
      PLN02467
      Location:1 → 501
      PLN02467; betaine aldehyde dehydrogenase

    2. NM_001198470.1 → NP_001185399.1  aldehyde dehydrogenase 10A8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4HXD2
      Conserved Domains (1) summary
      PLN02467
      Location:1 → 496
      PLN02467; betaine aldehyde dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S795.1

    Gene LinkOut

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