FANCM DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FANCM
Official Full Name: DEAD/DEAH box RNA helicase family protein
Primary source: TAIR:AT1G35530
Locus tag: AT1G35530
See related: Araport:AT1G35530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: At-FANCM; F15O4.40; Fanconi anemia complementation group M
Summary: Encodes FANCM, a highly conserved helicase that functions as a major factor limiting meiotic crossover formation. It is not directly involved in the repair of DNA lesions but suppresses spontaneous somatic homologous recombination via a RecQ helicase (At-RECQ4A)-independent pathway.
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Genomic context

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See FANCM in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 24

Sequence:: Chromosome: 1; NC_003070.9 (13089816..13097286)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.
Title: Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.
FIGL1 and FANCM represent barriers to crossover formation, one limiting strand invasion, the other disassembling D-loops to promote synthesis-dependent strand annealing, which when lifted, leads to a large increase of crossovers.
Title: AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms.
Data indicate that both topoisomerase3alpha (TOP3alpha) and RECQ4A/B helicases act independently of the anti-meiotic crossovers (COs) Fanconi anemia of complementation group M (FANCM) helicase.
Title: Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.
At-FANCM is not only a safeguard for genome stability in somatic cells but is an important factor in the control of meiotic crossover formation.
Title: The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis.
study identified the highly conserved FANCM helicase, as a major factor limiting meiotic crossover(CO)formation; FANCM is a key factor imposing an upper limit on the number of meiotic COs
Title: FANCM limits meiotic crossovers.

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General gene information

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NM_001198212.1

Supported by ESTs:

NM_001333161.1

Supported by ESTs:

NM_001333164.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of reciprocal meiotic recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DEAD/DEAH box RNA helicase family protein

NP_001185141.1

DEAD/DEAH box RNA helicase family protein; FUNCTIONS IN: in 6 functions; LOCATED IN: cellular_component unknown; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Restriction endonuclease, type I, R subunit/Type III, Res subunit (InterPro:IPR006935), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G36020.1).

NP_001319152.1

DEAD/DEAH box RNA helicase family protein; FUNCTIONS IN: in 6 functions; LOCATED IN: cellular_component unknown; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Restriction endonuclease, type I, R subunit/Type III, Res subunit (InterPro:IPR006935), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G36020.1); Has 20447 Blast hits to 20241 proteins in 2853 species: Archae - 674; Bacteria - 11662; Metazoa - 2557; Fungi - 1790; Plants - 1282; Viruses - 18; Other Eukaryotes - 2464 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

13089816..13097286

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001333162.1 → NP_001320963.1 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

I3XHK1, Q9LQE5

UniProtKB/TrEMBL

A0A178W771

Conserved Domains (1) summary

cl17041
Location:103 → 594

helicase_insert_domain; helicase_insert_domain
NM_001333163.1 → NP_001320964.1 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W771, A0A1P8APH5
NM_001333161.1 → NP_001319152.1 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A654EH21, F4HYE5
NM_001333164.1 → NP_001320965.1 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W777, A0A1P8APE5
NM_001198212.1 → NP_001185141.1 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185141.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W777, F4HYE4

Conserved Domains (4) summary

COG1111
Location:103 → 593

MPH1; ERCC4-related helicase [Replication, recombination and repair]

cd00046
Location:129 → 272

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd12091
Location:323 → 436

FANCM_ID; Insert domain of FANCM and related proteins

pfam00271
Location:446 → 572

Helicase_C; Helicase conserved C-terminal domain