GPX8 glutathione peroxidase 8 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: GPX8
Official Full Name: glutathione peroxidase 8
Primary source: TAIR:AT1G63460
Locus tag: AT1G63460
See related: Araport:AT1G63460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGPX8; F2K11.16; F2K11_16; glutathione peroxidase 8
Summary: Encodes GPX8 (glutathione peroxidase 8). Involved in the suppression of oxidative damages in nucleus and cytosol.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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the deficiency of AtGPX8 accelerates the progression of oxidative stress in knockout out plants.
Title: The importance of Arabidopsis glutathione peroxidase 8 for protecting Arabidopsis plant and E. coli cells against oxidative stress.
These results suggest that AtGPX8 plays an important role in the protection of cellular components including nuclear DNA against oxidative stress.
Title: The involvement of Arabidopsis glutathione peroxidase 8 in the suppression of oxidative damage in the nucleus and cytosol.

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NM_105025.4

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_564813.1

glutathione peroxidase 8 (GPX8); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: response to oxidative stress, oxidation reduction; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 6 (TAIR:AT4G11600.1); Has 7264 Blast hits to 7263 proteins in 1725 species: Archae - 2; Bacteria - 3448; Metazoa - 795; Fungi - 210; Plants - 387; Viruses - 8; Other Eukaryotes - 2414 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain