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    MOT2 sulfate transmembrane transporter [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844371, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MOT2
    Official Full Name
    sulfate transmembrane transporter
    Primary source
    TAIR:AT1G80310
    Locus tag
    AT1G80310
    See related
    Araport:AT1G80310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5I6.6; F5I6_6; molybdate transporter 2
    Summary
    MOT2 encodes a molybdate transporter which locates to the vacuolar membrane. Loss-of-function (knock out) mutants show elevated molydate levels in rosette leaves and in fully senescent leaves, but decreased MoO4 levels in seeds. Under conditions of molybdate deficiency leaves from mot2::tDNA mutants show strongly reduced nitrate reductase activity. The mot2 gene is slightly expressed in young and mature leaves, but strongly in senescing leaves. This observation points to a function of MOT2 in molybdate transfer from leaves to seeds during plant senescence.
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    Genomic context

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    See MOT2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (30194618..30196554)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene nucleotide transporter 1 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene gibberellin 3-oxidase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an Arabidopsis solute carrier critical for intracellular transport and inter-organ allocation of molybdate. Gasber A, et al. Plant Biol (Stuttg), 2011 Sep. PMID 21815974
    2. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_106680.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molybdate ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sulfate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within molybdate ion export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within molybdate ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfate transmembrane transporter
    NP_178147.1
    • sulfate transmembrane transporters; FUNCTIONS IN: sulfate transmembrane transporter activity; INVOLVED IN: response to salt stress; LOCATED IN: vacuole; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Sulphate transporter (InterPro:IPR011547); BEST Arabidopsis thaliana protein match is: molybdate transporter 1 (TAIR:AT2G25680.1); Has 846 Blast hits to 836 proteins in 367 species: Archae - 24; Bacteria - 581; Metazoa - 20; Fungi - 62; Plants - 71; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30194618..30196554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106680.3 → NP_178147.1  sulfate transmembrane transporter [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z3C0, Q0WP36, Q9C973
      UniProtKB/TrEMBL
      A0A178WGR3, A0A5S9WW05, A0A7G2E7K2
      Conserved Domains (1) summary
      pfam16983
      Location:272 → 390
      MFS_MOT1; Molybdate transporter of MFS superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WP36.2

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