U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TSC10A NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819779, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TSC10A
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT3G06060
    Locus tag
    AT3G06060
    See related
    Araport:AT3G06060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24F17.4; F24F17_4
    Summary
    Encodes one of the Arabidopsis proteins (At3g06060/TSC10A and At5g19200/TSC10B) with significant similarity to the yeast 3-ketodihydrosphinganine (3-KDS) reductase, Tsc10p. Both TSC10A and TSC10B are bona fide 3-KDS reductase as shown by complementation experiment in yeast.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TSC10A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (1827922..1830469, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L12/ ATP-dependent Clp protease adaptor protein ClpS family protein Neighboring gene peroxiredoxin IIF Neighboring gene uncharacterized protein Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. Chao DY, et al. Plant Cell, 2011 Mar. PMID 21421810, Free PMC Article
    2. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSC10A encodes a functionally redundant 3-KDS reductase required for sphingolipid synthesis.
      Title: Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help
    NM_111481.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-dehydrosphinganine reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-dehydrosphinganine reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3-keto-sphinganine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3-keto-sphinganine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_187257.2
    • NAD(P)-binding Rossmann-fold superfamily protein; FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT5G19200.1); Has 110611 Blast hits to 110370 proteins in 3576 species: Archae - 917; Bacteria - 74698; Metazoa - 5725; Fungi - 6415; Plants - 2635; Viruses - 0; Other Eukaryotes - 20221 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1827922..1830469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337630.1 → NP_001325788.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LMA8, A0A654F5R7

    2. NM_111481.3 → NP_187257.2  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187257.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WRJ2, Q9M7S9
      UniProtKB/TrEMBL
      A0A654F5R7
      Conserved Domains (2) summary
      cd08939
      Location:40 → 273
      KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
      pfam00106
      Location:40 → 228
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WRJ2.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools